Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1981 May;44(2):355–358.

Comparative effects of carrageenan on systemic candidiasis and listeriosis in mice.

B Hurtrel, P H Lagrange
PMCID: PMC1537360  PMID: 6796313

Abstract

Carrageenan, a toxic substance for the mononuclear phagocyte system (MPS), increase drastically the susceptibility of mice against Listeria monocytogenes challenge but induces concurrently an increasing resistance against systemic candidiasis and granulocytosis. These results corroborate the minor role played by MPS and suggest that polymorphonuclear cells play a major role in non-specific resistance of mice against systemic candidiasis.

Full text

PDF
355

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Harington J. S., Birbeck M. An examination of the cytotoxic effects of silica on macrophages. J Exp Med. 1966 Aug 1;124(2):141–154. doi: 10.1084/jem.124.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Catanzaro P. J., Schwartz H. J., Graham R. C., Jr Spectrum and possible mechanism of carrageenan cytotoxicity. Am J Pathol. 1971 Aug;64(2):387–404. [PMC free article] [PubMed] [Google Scholar]
  3. DAVIES G. E. INHIBITION OF COMPLEMENT BY CARRAGEENIN: MODE OF ACTION, EFFECT ON ALLERGIC REACTIONS AND ON COMPLEMENT OF VARIOUS SPECIES. Immunology. 1965 Mar;8:291–299. [PMC free article] [PubMed] [Google Scholar]
  4. Goren M. B., D'Arcy Hart P., Young M. R., Armstrong J. A. Prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2510–2514. doi: 10.1073/pnas.73.7.2510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hahn H., Bierther M. Morphological changes induced by dextran sulfate 500 in mononuclear phagocytes of listeria-infected mice. Infect Immun. 1974 Nov;10(5):1110–1119. doi: 10.1128/iai.10.5.1110-1119.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hahn H. Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice. Infect Immun. 1974 Nov;10(5):1105–1109. doi: 10.1128/iai.10.5.1105-1109.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hurtrel B., Lagrange P. H., Michel J. C. Systemic candidiasis in mice. II.--Main role of polymorphonuclear leukocytes in resistance to infection. Ann Immunol (Paris) 1980 Jan-Feb;131C(1):105–118. [PubMed] [Google Scholar]
  8. Leijh P. C., van den Barselaar M. T., van Furth R. Kinetics of phagocytosis and intracellular killing of Candida albicans by human granulocytes and monocytes. Infect Immun. 1977 Aug;17(2):313–318. doi: 10.1128/iai.17.2.313-318.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mankes R., Abraham R. Lysosomal dysfunction in colonic submucosal macrophages of rhesus monkeys caused by degraded iota carrageenan. Proc Soc Exp Biol Med. 1975 Oct;150(1):166–170. doi: 10.3181/00379727-150-38996. [DOI] [PubMed] [Google Scholar]
  10. Morelli R., Rosenberg L. T. The role of complement in the phagocytosis of Candida albicans by mouse peripheral blood leukocytes. J Immunol. 1971 Aug;107(2):476–480. [PubMed] [Google Scholar]
  11. Rogers T. J., Balish E. The role of activated macrophages in resistance to experimental renal candidiasis. J Reticuloendothel Soc. 1977 Oct;22(4):309–318. [PubMed] [Google Scholar]
  12. Ruthe R. C., Andersen B. R., Cunningham B. L., Epstein R. B. Efficacy of granulocyte transfusions in the control of systemic candidiasis in the leukopenic host. Blood. 1978 Sep;52(3):493–498. [PubMed] [Google Scholar]
  13. Sawicki J. E., Catanzaro P. J. Selective macrophage cytotoxicity of carrageenan in vivo. Int Arch Allergy Appl Immunol. 1975;49(5):709–714. doi: 10.1159/000231451. [DOI] [PubMed] [Google Scholar]
  14. Schwartz H. J., Kellermeyer R. W. Carrageenan and delayed hypersensitivity. II. Activation of Hageman factor by carrageenan and its possible significance. Proc Soc Exp Biol Med. 1969 Dec;132(3):1021–1024. doi: 10.3181/00379727-132-34358. [DOI] [PubMed] [Google Scholar]
  15. Sher N. A., Chaparas S. D., Greenberg L. E., Bernard S. Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice. Infect Immun. 1975 Dec;12(6):1325–1330. doi: 10.1128/iai.12.6.1325-1330.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Simon L., Jones T. L. Re-evaluation of carrageenan cytotoxicity for macrophages. J Reticuloendothel Soc. 1979 Feb;25(2):133–138. [PubMed] [Google Scholar]
  17. Tatsukawa K., Mitsuyama M., Takeya K., Nomoto K. Differing contribution of polymorphonuclear cells and macrophages to protection of mice against Listeria monocytogenes and Pseudomonas aeruginosa. J Gen Microbiol. 1979 Nov;115(1):161–166. doi: 10.1099/00221287-115-1-161. [DOI] [PubMed] [Google Scholar]
  18. Williams D. L., Cook J. A., Hoffmann E. O., Di Luzio N. R. Protective effect of glucan in experimentally induced candidiasis. J Reticuloendothel Soc. 1978 Jun;23(6):479–490. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES