Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1978 Dec;34(3):359–363.

Trypanosomiasis leads to extensive proliferation of B, T and null cells in spleen and bone marrow

K S Mayor Withey, Christine E Clayton, G E Roelants, B A Askonas
PMCID: PMC1537537  PMID: 311257

Abstract

Changes in the distribution of T, B and null cells in the spleen and bone marrow have been studied in inbred mice infected with Trypanosoma brucei. Immunofluorescent staining combined with a 3H-thymidine pulse and autoradiography showed activation of all three cell types. A transient increase in splenic T cells was followed by dramatic increases in B cells (2·5-fold) and in null cells (35-fold). By day 12, after the first peak of parasitaemia, nearly half the spleen cells were dividing. In the bone marrow, very large blast cells appeared within a week of infection.

Full text

PDF
359

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Askonas B. A., Roelants G. E., Mayor-Withey K. S., Welstead J. L. Dual pathway of B lymphocyte differentiation in vitro. Eur J Immunol. 1976 Apr;6(4):250–256. doi: 10.1002/eji.1830060404. [DOI] [PubMed] [Google Scholar]
  2. Corsini A. C., Clayton C., Askonas B. A., Ogilvie B. M. Suppressor cells and loss of B-cell potential in mice infected with Trypanosoma brucei. Clin Exp Immunol. 1977 Jul;29(1):122–131. [PMC free article] [PubMed] [Google Scholar]
  3. Eardley D. D., Jayawardena A. N. Suppressor cells in mice infected with Trypanosoma brucei. J Immunol. 1977 Sep;119(3):1029–1033. [PubMed] [Google Scholar]
  4. Goodwin L. G., Green D. G., Guy M. W., Voller A. Immunosuppression during trypanosomiasis. Br J Exp Pathol. 1972 Feb;53(1):40–43. [PMC free article] [PubMed] [Google Scholar]
  5. Goodwin L. G. The pathology of African trypanosomiasis. Trans R Soc Trop Med Hyg. 1970;64(6):797–817. doi: 10.1016/0035-9203(70)90096-9. [DOI] [PubMed] [Google Scholar]
  6. Greenwood B. M., Whittle H. C., Molyneux D. H. Immunosuppression in Gambian trypanosomiasis. Trans R Soc Trop Med Hyg. 1973;67(6):846–850. doi: 10.1016/0035-9203(73)90013-8. [DOI] [PubMed] [Google Scholar]
  7. Hudson K. M., Byner C., Freeman J., Terry R. J. Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis. Nature. 1976 Nov 18;264(5583):256–258. doi: 10.1038/264256a0. [DOI] [PubMed] [Google Scholar]
  8. Jayawardena A. N., Waksman B. H. Suppressor cells in experimentally trypanosomiasis. Nature. 1977 Feb 10;265(5594):539–541. doi: 10.1038/265539a0. [DOI] [PubMed] [Google Scholar]
  9. Jennings F. W., Urquhart G. M., Murray M. Trypanosoma brucei infections in mice: studies on the anaemia. Trans R Soc Trop Med Hyg. 1972;66(2):342–342. doi: 10.1016/0035-9203(72)90224-6. [DOI] [PubMed] [Google Scholar]
  10. Loor F., Roelants G. E. Immunofluorescence studies of a possible prethymic T-cell differentiation in congenitally athymic (nude) mice. Ann N Y Acad Sci. 1975 Jun 30;254:226–241. doi: 10.1111/j.1749-6632.1975.tb29173.x. [DOI] [PubMed] [Google Scholar]
  11. Morrison W. I., Roelants G. E., Mayor-Withey K. S., Murray M. Susceptibility of inbred strains of mice to Trypanosoma congolense: correlation with changes in spleen lymphocyte populations. Clin Exp Immunol. 1978 Apr;32(1):25–40. [PMC free article] [PubMed] [Google Scholar]
  12. Murray P. K., Jennings F. W., Murray M., Urquhart G. M. The nature of immunosuppression in Trypanosoma brucei infections in mice. I. The role of the macrophage. Immunology. 1974 Nov;27(5):815–824. [PMC free article] [PubMed] [Google Scholar]
  13. Murray P. K., Jennings F. W., Murray M., Urquhart G. M. The nature of immunosuppression in Trypanosoma brucei infections in mice. II. The role of the T and B lymphocytes. Immunology. 1974 Nov;27(5):825–840. [PMC free article] [PubMed] [Google Scholar]
  14. Pearson T. W., Roelants G. E., Lundin L. B., Mayor-Withey K. S. Immune depression in trypanosome-infected mice. I. Depressed T lymphocyte responses. Eur J Immunol. 1978 Oct;8(10):723–727. doi: 10.1002/eji.1830081010. [DOI] [PubMed] [Google Scholar]
  15. Roelants G. E., Loor F., von Boehmer H., Sprent J., Hägg L. B., Mayor K. S., Rydén A. Five types of lymphocytes (Ig-theta-, Ig-theta+weak, Ig-theta+strong, Ig+theta- and Ig+theta+) characterized by double immunofluorescence and electrophoretic mobility. Organ distribution in normal and nude mice. Eur J Immunol. 1975 Feb;5(2):127–131. doi: 10.1002/eji.1830050211. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES