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. 1978 Dec;34(3):441–448.

Effects of placental tissue on immunological responses

Michele Barg, R C Burton, Judith A Smith, G A Luckenbach, Jan Decker, G F Mitchell
PMCID: PMC1537542  PMID: 33776

Abstract

Using in vivo assays for alloreactivity, the responsiveness of maternal lymph node cells was shown to be increased when cells were harvested from both syngeneically and allogeneically pregnant mice. In addition, foetal liver and thymus cells induced a state of delayed type hypersensitivity to alloantigens whereas trophoblastic tissue, in the form of 12 to 15 day metrial glands, did not.

The influence of mouse placenta on in vitro immune responses was tested using 7-day ectoplacental cones as sources of trophoblastic tissue. Ectoplacental cones increased a T cell dependent but not a T cell independent antibody response, whereas T cell dependent cytotoxicity was reduced. The findings reported in this paper suggest that murine ectoplacental cones are a particularly useful tissue with which to study both specific and non-specific immunological activities of the trophoblast in syngeneic and allogeneic pregnancies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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