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. 1978 Dec;34(3):388–392.

Primary and secondary abnormalities of T cell subpopulations

R S Trompeter, L Layward, A R Hayward
PMCID: PMC1537549  PMID: 311259

Abstract

Ataxia telangiectasia patients had normal numbers of T lymphocytes in their blood but IgM-binding T lymphocytes (TM) were selectively reduced. These changes provide a cellular basis for the defects in cell-mediated immunity which occur in this primary condition. One child with severe combined immunodeficiency lacked both TM and IgG-binding (TG) T lymphocytes, but no consistent abnormalities of T cell subsets were found in other primary immunodeficiency syndromes. Secondary increases in IgG-binding T lymphocytes (TG) were found in children receiving steroids.

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Selected References

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