Abstract
The distribution of IgA 1 and IgA 2 plasma cells was studied in normal human tissues. IgA 2 is a minor constituent in peripheral lymph nodes as well as in serum and in bone marrow plasma cells. An increased proportion of IgA 2 plasma cells was observed in gastric and intestinal mucosa, as well as in bronchial mucosa and salivary and mammary glands. Tonsils and mesenteric lymph nodes exhibit values intermediate between those of central and peripheral lymphoid systems. In patients with plasma IgA-deficiency, IgA 2 is the predominant intestinal IgA plasma cells. This may explain the frequent association of an asymptomatic condition and plasma IgA deficiency.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- André F., André C. Participation de l'immunoglobuline A monomérique et dimérique à l'hypergammaglobulinémie de la cirrhose éthylique. Biol Gastroenterol (Paris) 1976 Apr-May;9(2):147–150. [PubMed] [Google Scholar]
- Brandtzaeg P., Baklien K., Fausa O., Hoel P. S. Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology. 1974 Jun;66(6):1123–1136. [PubMed] [Google Scholar]
- Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique. Immunology. 1974 Jun;26(6):1101–1114. [PMC free article] [PubMed] [Google Scholar]
- Broom B. C., de la Concha E. G., Webster A. D., Loewi G., Asherson G. L. Dichotomy between immunoglobulin synthesis by cells in gut and blood of patients with hypogammaglobulinaemia. Lancet. 1975 Aug 9;2(7928):253–256. doi: 10.1016/s0140-6736(75)90965-4. [DOI] [PubMed] [Google Scholar]
- Grey H. M., Abel C. A., Yount W. J., Kunkel H. G. A subclass of human gamma-A-globulins (gamma-A2) which lacks the disulfied bonds linking heavy and light chains. J Exp Med. 1968 Dec 1;128(6):1223–1236. doi: 10.1084/jem.128.6.1223. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Matuchansky C., Galian A., Goldfain D., Rambaud J. C., Modigliani R., Bernier J. J. Immunocytes et immunoglobulines du tube digestif au cours des déficits immunitaires primitifs de l'adulte. Etude de 26 cas. Gastroenterol Clin Biol. 1977 Apr;1(4):331–343. [PubMed] [Google Scholar]
- Skvaril F., Morell A. Distribution of IgA subclasses in sera and bone marrow plasma cells of 21 normal individuals. Adv Exp Med Biol. 1974;45(0):433–435. doi: 10.1007/978-1-4613-4550-3_51. [DOI] [PubMed] [Google Scholar]