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. 1979 Mar;35(3):329–337.

The role of circulating immune complexes in the glomerular disease of experimental hepatosplenic schistosomiasis.

M Digeon, D Droz, L H Noel, J Riza, C Rieumailhol, J F Bach, F Santoro, A Capron
PMCID: PMC1537623  PMID: 378479

Abstract

The serological and renal changes were studied simultaneously in 115 mice infected with Schistosoma mansoni. IgG and IgM, but not IgA anti-S. mansoni antibodies were detected in the sera, together with circulating immune complexes containing schistosomal antigen. Glomerular mesangial deposits of IgA, IgM and C3 were observed. Despite the strong correlation observed between the occurrence of the circulating immune complexes containing schistosomal antigen and the glomerular deposits, results concerning the behaviour of IgA suggest that portal hypertension and liver damage have a role in the pathogenesis of glomerular lesions.

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Selected References

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