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. 1979 Jul;37(1):7–14.

Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.

D J Bradley, B A Taylor, J Blackwell, E P Evans, J Freeman
PMCID: PMC1537668  PMID: 290436

Abstract

Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACTOR P. Protein and vitamin intake and visceral leishmaniasis in the mouse. Exp Parasitol. 1960 Sep;10:1–20. doi: 10.1016/0014-4894(60)90078-3. [DOI] [PubMed] [Google Scholar]
  2. Bang F. B., Warwick A. MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITY. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1065–1075. doi: 10.1073/pnas.46.8.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bodmer W. F. The HLA system: introduction. Br Med Bull. 1978 Sep;34(3):213–216. doi: 10.1093/oxfordjournals.bmb.a071500. [DOI] [PubMed] [Google Scholar]
  4. Bradley D. J., Kirkley J. Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice. Clin Exp Immunol. 1977 Oct;30(1):119–129. [PMC free article] [PubMed] [Google Scholar]
  5. Bradley D. J. Letter: Genetic control of natural resistance to Leishmania donovani. Nature. 1974 Jul 26;250(464):353–354. doi: 10.1038/250353a0. [DOI] [PubMed] [Google Scholar]
  6. Bradley D. J. Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin Exp Immunol. 1977 Oct;30(1):130–140. [PMC free article] [PubMed] [Google Scholar]
  7. Festenstein H. The Mls system. Transplant Proc. 1976 Sep;8(3):339–342. [PubMed] [Google Scholar]
  8. Groves M. G., Osterman J. V. Host defenses in experimental scrub typhus: genetics of natural resistance to infection. Infect Immun. 1978 Feb;19(2):583–588. doi: 10.1128/iai.19.2.583-588.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Haldane J B, Waddington C H. Inbreeding and Linkage. Genetics. 1931 Jul;16(4):357–374. doi: 10.1093/genetics/16.4.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lilly F. The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529–539. doi: 10.1093/genetics/53.3.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lonai P., Haran-Ghera N. Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex. J Exp Med. 1977 Oct 1;146(4):1164–1168. doi: 10.1084/jem.146.4.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Plant J., Glynn A. A. Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis. 1976 Jan;133(1):72–78. doi: 10.1093/infdis/133.1.72. [DOI] [PubMed] [Google Scholar]
  13. Plant J., Glynn A. A. Locating salmonella resistance gene on mouse chromosome 1. Clin Exp Immunol. 1979 Jul;37(1):1–6. [PMC free article] [PubMed] [Google Scholar]
  14. Taylor B. A., Bedigian H. G., Meier H. Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines. J Virol. 1977 Jul;23(1):106–109. doi: 10.1128/jvi.23.1.106-109.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Watson J. G., Higgins T. J., Collins P. B., Chaykin S. The mouse liver aldehyde oxidase locus (Aox). Biochem Genet. 1972 Apr;6(2):195–204. doi: 10.1007/BF00486403. [DOI] [PubMed] [Google Scholar]
  16. Zinkernagel R. M., Althage A., Adler B., Blanden R. V., Davidson W. F., Kees U., Dunlop M. B., Shreffler D. C. H-2 restriction of cell-mediated immunity to an intracellular bacterium: effector T cells are specific for Listeria antigen in association with H-21 region-coded self-markers. J Exp Med. 1977 May 1;145(5):1353–1367. doi: 10.1084/jem.145.5.1353. [DOI] [PMC free article] [PubMed] [Google Scholar]

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