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. 1979 Apr;36(1):183–188.

Human immunoglobulin D in colostrum, saliva and amniotic fluid.

H F Sewell, J B Matthews, V Flack, R Jefferis
PMCID: PMC1537701  PMID: 111882

Abstract

An antiserum raised to a partially purified preparation of secretory IgA isolated from human colostrum was shown to contain antibodies directed against human IgD. The inferred presence of IgD in the human colostrum was confirmed and also its association with antibody activity, as demonstrated by the presence of anti-E. coli antibodies. IgD was also shown to be present in whole saliva, parotid saliva and amniotic fluid, but could not be detected in jejunal juice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahlstedt S., Carlsson B., Hanson L. A., Goldblum R. M. Antibody production by human colostral cells. I. Immunoglobulin class, specificity, and quantity. Scand J Immunol. 1975 Sep;4(5-6):535–539. doi: 10.1111/j.1365-3083.1975.tb02659.x. [DOI] [PubMed] [Google Scholar]
  2. Brandtzaeg P. Human secretory immunoglobulins. II. Salivary secretions from individuals with selectively excessive or defective synthesis of serum immunoglobulins. Clin Exp Immunol. 1971 Jan;8(1):69–85. [PMC free article] [PubMed] [Google Scholar]
  3. CHODIRKER W. B., TOMASI T. B., Jr GAMMA-GLOBULINS: QUANTITATIVE RELATIONSHIPS IN HUMAN SERUM AND NONVASCULAR FLUIDS. Science. 1963 Nov 22;142(3595):1080–1081. doi: 10.1126/science.142.3595.1080. [DOI] [PubMed] [Google Scholar]
  4. Dunnette S. L., Gleich G. J., Miller R. D., Kyle R. A. Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol. 1977 Nov;119(5):1727–1731. [PubMed] [Google Scholar]
  5. Goding J. W. The chromic chloride method of coupling antigens to erythrocytes: definition of some important parameters. J Immunol Methods. 1976;10(1):61–66. doi: 10.1016/0022-1759(76)90007-7. [DOI] [PubMed] [Google Scholar]
  6. HANSON L. A. Comparative immunological studies of the immune globulins of human milk and of blood serum. Int Arch Allergy Appl Immunol. 1961;18:241–267. doi: 10.1159/000229177. [DOI] [PubMed] [Google Scholar]
  7. Halpern M. S., Koshland M. E. Noval subunit in secretory IgA. Nature. 1970 Dec 26;228(5278):1276–1278. doi: 10.1038/2281276a0. [DOI] [PubMed] [Google Scholar]
  8. Jefferis R., Mathews J. B. Studies of human IgD myeloma proteins. Proteolytic digestion patterns. Immunochemistry. 1977 Mar;14(3):171–178. doi: 10.1016/0019-2791(77)90191-4. [DOI] [PubMed] [Google Scholar]
  9. Johansson S. G., Berg T. Immunoglobulin levels in healthy children. Acta Paediatr Scand. 1967 Nov;56(6):572–579. doi: 10.1111/j.1651-2227.1967.tb15982.x. [DOI] [PubMed] [Google Scholar]
  10. Ling N. R., Bishop S., Jefferis Use of antibody-coated red cells for the sensitive detection of antigen and in rosette tests for cells bearing surface immunoglobulins. J Immunol Methods. 1977;15(3):279–289. doi: 10.1016/0022-1759(77)90065-5. [DOI] [PubMed] [Google Scholar]
  11. Ogra S. S., Weintraub D., Ogra P. L. Immunologic aspects of human colostrum and milk. III. Fate and absorption of cellular and soluble components in the gastrointestinal tract of the newborn. J Immunol. 1977 Jul;119(1):245–248. [PubMed] [Google Scholar]
  12. Rowe D. S., Crabbé P. A., Turner M. W. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin Exp Immunol. 1968 Jul;3(6):477–490. [PMC free article] [PubMed] [Google Scholar]
  13. Sewell H. F., Chambers L., Maxwell V., Matthews J. B., Jefferis R. The natural antibody response to E. coli includes antibodies of the IgD class. Clin Exp Immunol. 1978 Jan;31(1):104–110. [PMC free article] [PubMed] [Google Scholar]
  14. TOMASI T. B., Jr, TAN E. M., SOLOMON A., PRENDERGAST R. A. CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS. J Exp Med. 1965 Jan 1;121:101–124. doi: 10.1084/jem.121.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Walker W. A., Wu M., Isselbacher K. J., Bloch K. J. Intestinal uptake of macromolecules. III. Studies on the mechanism by which immunization interferes with antigen uptake. J Immunol. 1975 Sep;115(3):854–861. [PubMed] [Google Scholar]
  16. Warshaw A. L., Walker W. A., Isselbacher K. J. Protein uptake by the intestine: evidence for absorption of intact macromolecules. Gastroenterology. 1974 May;66(5):987–992. [PubMed] [Google Scholar]

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