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. 1979 Jun;36(3):364–370.

Immunological investigation in adenine phosphoribosyl transferase (APRT) deficiency.

W J Stevens, M E Peetermans, K J Van Acker
PMCID: PMC1537751  PMID: 487640

Abstract

In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins and determining lymphocyte membrane immunoglobulins by immunofluorescence. Delayed cutaneous hypersensitivity was also assayed. The absence of gross immunological deficiency in the homozygotes, as well as in the heterozygotes, suggests that the APRT-mediated pathway of purine metabolism is relatively unimportant for lymphocyte function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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