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. 1979 Sep;37(3):424–431.

Demonstration of two disease specific antigens in circulating immune complexes.

C Dambuyant, J Burton-Kee, J F Mowbray
PMCID: PMC1537766  PMID: 92380

Abstract

A method is described to assess antigenic cross-reactivity between soluble immune complexes precipitated from sera with polyethylene glycol. The precipitated complex from one serum was dissociated in acid and used to coat a plastic cup. Radioiodinated complexes from another serum were dissociated in the cup, neutralized and allowed to reassociate overnight. The binding of the labelled complex was used to measure the cross-reactivity between the complexes. Using this technique, complexes from a group of patients with haematuria and hypertension have been found to share an antigen, and a different antigen was found in patients with bullous pemphigoid. The participation of rheumatoid factors in the cross-reactions is unlikely, and no cross-reactivity of either group was found with sera from patients with rheumatoid arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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