Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1979 Aug;37(2):221–227.

Circulating immune complexes in acute schistosomiasis.

T J Lawley, E A Ottesen, R A Hiatt, L A Gazze
PMCID: PMC1537804  PMID: 498584

Abstract

The sera of patients with acute and chronic schistosomasis were tested for the presence of circulating immune complexes with the 125I-Clq binding assay. Fourteen out of fifteen (93%) patients with acute schistosomiasis had elevated 125I-Clq binding activity, while only two out of eleven (18%) patients with chronic disease had C1q binding complexes. This difference was significant (P less than 0.001) and paralleled the degree of clinical didsease activity between the two groups of patients. IgG and IgM were readily detected in all of these circulating complexes but the specific parasite antigens initiating their formation could not be defined. The level of circulating immune complexes was inversely correlated with the absolute eosinophil counts for individuals in the acutely infected group, an observation compatible wiht the hypothesis that a functional role for the eosinophil is the destruction and elimination of immune complexes.

Full text

PDF
221

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrade Z. A., de Queiroz A. C. Lesões renais na esquistossomose hepatesplênica. Rev Inst Med Trop Sao Paulo. 1968 Jan-Feb;10(1):36–40. [PubMed] [Google Scholar]
  2. Berggren W. L., Weller T. H. Immunoelectrophoretic demonstration of specific circulating antigen in animals infected with Schistosoma mansoni. Am J Trop Med Hyg. 1967 Sep;16(5):606–612. doi: 10.4269/ajtmh.1967.16.606. [DOI] [PubMed] [Google Scholar]
  3. Bolton A. E., Hunter W. M. The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Biochem J. 1973 Jul;133(3):529–539. doi: 10.1042/bj1330529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bout D., Santoro F., Carlier Y., Bina J. C., Capron A. Circulating immune complexes in schistosomiasis. Immunology. 1977 Jul;33(1):17–22. [PMC free article] [PubMed] [Google Scholar]
  5. CHAFFEE E. F., BAUMAN P. M., SHAPILO J. J. Diagnosis of schistosomiasis by complement-fixation. Am J Trop Med Hyg. 1954 Sep;3(5):905–913. doi: 10.4269/ajtmh.1954.3.905. [DOI] [PubMed] [Google Scholar]
  6. Cline B. L., Rymzo W. T., Hiatt R. A., Knight W. B., Berríos-Duran L. A. Morbidity from Schistosoma mansoni in a Puerto Rican community: a population-based study. Am J Trop Med Hyg. 1977 Jan;26(1):109–117. doi: 10.4269/ajtmh.1977.26.109. [DOI] [PubMed] [Google Scholar]
  7. Falcão H. A., Gould D. B. Immune complex nephropathy i schistosomiasis. Ann Intern Med. 1975 Aug;83(2):148–154. doi: 10.7326/0003-4819-83-2-148. [DOI] [PubMed] [Google Scholar]
  8. Hoshino-Shimizu S., De Brito T., Kanamura H. Y., Canto A. L., Silva A. O., Campos A. R., Penna D. O., Da Silva L. C. Human schistosomiasis: Schistosoma mansoni antigen detection in renal glomeruli. Trans R Soc Trop Med Hyg. 1976;70(5-6):492–496. doi: 10.1016/0035-9203(76)90135-8. [DOI] [PubMed] [Google Scholar]
  9. Ishikawa T., Wicher K., Arbesman C. E. In vitro and in vivo studies on uptake of antigen-antibody complexes by eosinophils. Int Arch Allergy Appl Immunol. 1974;46(2):230–248. doi: 10.1159/000231126. [DOI] [PubMed] [Google Scholar]
  10. Nash T. E., Prescott B., Neva F. A. The characteristics of a circulating antigen in schistosomiasis. J Immunol. 1974 Apr;112(4):1500–1507. [PubMed] [Google Scholar]
  11. Nydegger U. E., Zubler R. H., Gabay R., Joliat G., Karagevrekis C. H., Lambert P. H., Miescher P. A. Circulating complement breakdown products in patients with rheumatoid arthritis. Correlation between plasma C3d, circulating immune complexes, and clinical activity. J Clin Invest. 1977 May;59(5):862–868. doi: 10.1172/JCI108708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ottesen E. A., Hiatt R. A., Cheever A. W., Sotomayor Z. R., Neva F. A. The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man. Clin Exp Immunol. 1978 Jul;33(1):37–47. [PMC free article] [PubMed] [Google Scholar]
  13. Queiroz P. F., Brito E., Martinelli R., Rocha H. Nephrotic syndrome in patients with Schistosoma mansoni infection. Am J Trop Med Hyg. 1973 Sep;22(5):622–628. doi: 10.4269/ajtmh.1973.22.622. [DOI] [PubMed] [Google Scholar]
  14. Warren K. S. Schistosomiasis: a multiplicity of immunopathology. J Invest Dermatol. 1976 Sep;67(3):464–469. doi: 10.1111/1523-1747.ep12514738. [DOI] [PubMed] [Google Scholar]
  15. Yonemasu K., Stroud R. M. Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. J Immunol. 1971 Feb;106(2):304–313. [PubMed] [Google Scholar]
  16. da Silva L. C., de Brito T., Camargo M. E., de Boni D. R., Lopes J. D., Gunji J. Kidney biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man. Bull World Health Organ. 1970;42(6):907–910. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES