Abstract
Murine cytomegalovirus (CMV) causes depression of cell-mediated immunity. Skin graft survival is significantly prolonged across the strong H-2 and weak H-Y histocompatibility barriers in mice previously infected with CMV. Maximum prolongation of skin graft survival across the H-2 barrier occurred in mice infected on the day of grafting and survival was significantly prolonged in mice infected up to 5 days before grafting.
CMV also inhibited uptake of tritiated thymidine by spleen cells in response to pytohaemagglutinin (PHA) or in mixed lymphocyte culture. Inhibition of responsiveness to PHA occurred for up to 26 days after infection. Uptake of tritiated thymidine was significantly elevated over controls 5 days after infection but not after this time.
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- Adler W. H., Takiguchi T., Smith R. T. Effect of age upon primary alloantigen recognition by mouse spleen cells. J Immunol. 1971 Nov;107(5):1357–1367. [PubMed] [Google Scholar]
- Howard R. J., Najarian J. S. Cytomegalovirus-induced immune suppression. I. Humoral immunity. Clin Exp Immunol. 1974 Sep;18(1):109–118. [PMC free article] [PubMed] [Google Scholar]
- Kantor G. L., Goldberg L. S., Johnson B. L., Jr, Derechin M. M., Barnett E. V. Immunologic abnormalities induced by postperfusion cytomegalovirus infection. Ann Intern Med. 1970 Oct;73(4):553–558. doi: 10.7326/0003-4819-73-4-553. [DOI] [PubMed] [Google Scholar]
- Lopez C., Simmons R. L., Mauer S. M., Najarian J. S., Good R. A., Gentry S. Association of renal allograft rejection with virus infections. Am J Med. 1974 Mar;56(3):280–289. doi: 10.1016/0002-9343(74)90609-3. [DOI] [PubMed] [Google Scholar]
- Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
- Osborn J. E., Blazkovec A. A., Walker D. L. Immunosuppression during acute murine cytomegalovirus infection. J Immunol. 1968 Apr;100(4):835–844. [PubMed] [Google Scholar]
- Osborn J. E., Walker D. L. Virulence and attenuation of murine cytomegalovirus. Infect Immun. 1971 Feb;3(2):228–236. doi: 10.1128/iai.3.2.228-236.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]