Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1974 Sep;18(1):81–87.

Reduction of a subpopulation of T lymphocytes in lepromatous leprosy

Indira Nath, Jill Curtis, L K Bhutani, G P Talwar
PMCID: PMC1537983

Abstract

A reduction in number of a subpopulation of T lymphocytes was noted in lepromatous leprosy cases with high bacillary load. Tuberculoid and treated lepromatous patients, who were bacillary negative had normal levels of these cells. B-cell numbers were high in lepromatous patients irrespective of treatment and bacillary load.

Full text

PDF
81

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bullock W. E., Jr, Fasal P. Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response. J Immunol. 1971 Apr;106(4):888–899. [PubMed] [Google Scholar]
  3. Dierks R. E., Shepard C. C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc Soc Exp Biol Med. 1968 Feb;127(2):391–395. doi: 10.3181/00379727-127-32698. [DOI] [PubMed] [Google Scholar]
  4. Dwyer J. M., Bullock W. E., Fields J. P. Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy. Clinical and immunologic correlations. N Engl J Med. 1973 May 17;288(20):1036–1039. doi: 10.1056/NEJM197305172882002. [DOI] [PubMed] [Google Scholar]
  5. Gajl-Peczalska K. J., Lim S. D., Jacobson R. R., Good R. A. B lymphocytes in lepromatous leprosy. N Engl J Med. 1973 May 17;288(20):1033–1035. doi: 10.1056/NEJM197305172882001. [DOI] [PubMed] [Google Scholar]
  6. Godal T., Myklestad B., Samuel D. R., Myrvang B. Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes. Clin Exp Immunol. 1971 Dec;9(6):821–831. [PMC free article] [PubMed] [Google Scholar]
  7. Godal T., Myrvang B., Froland S. S., Shao J., Melaku G. Evidence that the mechanism of immunological tolerance ("central failure") is operative in the lack of host resistance in lepromatous leprosy. Scand J Immunol. 1972;1(4):311–321. doi: 10.1111/j.1365-3083.1972.tb03296.x. [DOI] [PubMed] [Google Scholar]
  8. Katz S. I., DeBetz B. H., Zaias N. Production of macrophage inhibitory factor by patients with leprosy. Arch Dermatol. 1971 Apr;103(4):358–361. [PubMed] [Google Scholar]
  9. Mehra V. L., Talwar G. P., Balakrishnan K., Bhutani L. K. Influence of chemotherapy and serum factors on the mitogenic response of peripheral leucocytes of leprosy patients to phytohaemagglutinin. Clin Exp Immunol. 1972 Oct;12(2):205–213. [PMC free article] [PubMed] [Google Scholar]
  10. Mogensen C. E. The glomerular permeability determined by dextran clearance using Sephadex gel filtration. Scand J Clin Lab Invest. 1968;21(1):77–82. doi: 10.3109/00365516809076979. [DOI] [PubMed] [Google Scholar]
  11. Ridley D. S., Jopling W. H. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255–273. [PubMed] [Google Scholar]
  12. Talwar G. P., Krishnan A. D., Mehra V. L., Blum E. A., Pearson J. M. Evaluation of cell mediated immune responses in untreated cases of leprosy. Clin Exp Immunol. 1972 Oct;12(2):195–203. [PMC free article] [PubMed] [Google Scholar]
  13. Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]
  14. Turk J. L., Waters M. F. Cell-mediated immunity in patients with leprosy. Lancet. 1969 Aug 2;2(7614):243–246. doi: 10.1016/s0140-6736(69)90009-9. [DOI] [PubMed] [Google Scholar]
  15. Turk J. L., Waters M. F. Immunological significance of changes in lymph nodes across the leprosy spectrum. Clin Exp Immunol. 1971 Mar;8(3):363–376. [PMC free article] [PubMed] [Google Scholar]
  16. Wybran J., Fudenberg H. H. Thymus-derived rosette-forming cells. N Engl J Med. 1973 May 17;288(20):1072–1073. doi: 10.1056/NEJM197305172882011. [DOI] [PubMed] [Google Scholar]
  17. Wybran J., Levin A. S., Spitler L. E., Fudenberg H. H. Rosette-forming cells, immunologic deficiency diseases and transfer factor. N Engl J Med. 1973 Apr 5;288(14):710–713. doi: 10.1056/NEJM197304052881405. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES