Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1974 Dec;18(4):461–467.

Cell-mediated immunity in diabetes mellitus*

G Delespesse, J Duchateau, P A Bastenie, J P Lauvaux, H Collet, A Govaerts
PMCID: PMC1538014  PMID: 4283119

Abstract

The quantified lymphocyte response to phytohaemagglutin (PHA) was investigated in fifty-six control subjects, classed according to age and sex, in twenty-nine insulin-dependent (IDD) and eight non-insulin-dependent diabetics. In nine cases one-way mixed lymphocyte cultures (MLC) were performed using mixed lymphocytes from IDD and paired controls. In the controls, a reduction of the response to PHA was observed with ageing; this was more marked in women than in men. The diabetics gave a greatly impaired response to PHA but only a slightly depressed response in MLC. These anomalies are not influenced by age but by the severity of the diabetes.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach F. H., Voynow N. K. One-way stimulation in mixed leukocyte cultures. Science. 1966 Jul 29;153(3735):545–547. doi: 10.1126/science.153.3735.545. [DOI] [PubMed] [Google Scholar]
  2. Brody J. I., Merlie K. Metabolic and biosynthetic features of lymphocytes from patients with diabetes mellitus: similarities to lymphocytes in chronic lymphocytic leukaemia. Br J Haematol. 1970 Aug;19(2):193–201. doi: 10.1111/j.1365-2141.1970.tb01616.x. [DOI] [PubMed] [Google Scholar]
  3. EISERT J. DIABETES AND DISEASES OF THE SKIN. Med Clin North Am. 1965 May;49:621–632. doi: 10.1016/s0025-7125(16)33311-9. [DOI] [PubMed] [Google Scholar]
  4. Fudenberg H., Good R. A., Goodman H. C., Hitzig W., Kunkel H. G., Roitt I. M., Rosen F. S., Rowe D. S., Seligmann M., Soothill J. R. Primary immunodeficiencies. Report of a World Health Organization Committee. Pediatrics. 1971 May;47(5):927–946. [PubMed] [Google Scholar]
  5. Hagen C., Froland A. Depressed lymphocyte response to P.H.A. in women taking oral contraceptives. Lancet. 1972 May 27;1(7761):1185–1185. doi: 10.1016/s0140-6736(72)91415-8. [DOI] [PubMed] [Google Scholar]
  6. Heine K. M., Stobbe H., Klatt R., Sahi J., Herrmann H. Lymphocyte function in the aged. Helv Med Acta. 1971 May;35(6):484–489. [PubMed] [Google Scholar]
  7. Hosking C. S., Fitzgerald M. G., Simons M. J. Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases. Clin Exp Immunol. 1971 Oct;9(4):467–476. [PMC free article] [PubMed] [Google Scholar]
  8. Lindahl-Kiessling K., Peterson R. D. The mechanism of phytohemagglutinin (PHA) action. 3. Stimulation of lymphocytes by allogeneic lymphocytes and phytohemagglutinin. Exp Cell Res. 1969 Apr;55(1):85–87. doi: 10.1016/0014-4827(69)90460-1. [DOI] [PubMed] [Google Scholar]
  9. Mackaness G. B. The J. Burns Amberson LECTURE The induction and expression of cell-mediated hypersensitivity in the lung. Am Rev Respir Dis. 1971 Dec;104(6):813–828. doi: 10.1164/arrd.1971.104.6.813. [DOI] [PubMed] [Google Scholar]
  10. Meuwissen H. J., Bach F. H., Hong R., Good R. A. Lymphocyte studies in congenital thymic dysplasia: The one-way stimulation test. J Pediatr. 1968 Feb;72(2):177–185. doi: 10.1016/s0022-3476(68)80306-3. [DOI] [PubMed] [Google Scholar]
  11. Mowat A., Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. N Engl J Med. 1971 Mar 25;284(12):621–627. doi: 10.1056/NEJM197103252841201. [DOI] [PubMed] [Google Scholar]
  12. Oppenheim J. J., Blaese R. M., Waldmann T. A. Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome. J Immunol. 1970 Apr;104(4):835–844. [PubMed] [Google Scholar]
  13. PERILLIE P. E., NOLAN J. P., FINCH S. C. Studies of the resistance to infection in diabetes mellitus: local exudative cellular response. J Lab Clin Med. 1962 Jun;59:1008–1015. [PubMed] [Google Scholar]
  14. Pentycross C. R. Lymphocyte transformation in young people. Clin Exp Immunol. 1969 Jul;5(1):213–216. [PMC free article] [PubMed] [Google Scholar]
  15. Pisciotta A. V., Westring D. W., DePrey C., Walsh B. Mitogenic effect of phytohaemagglutinin at different ages. Nature. 1967 Jul 8;215(5097):193–194. doi: 10.1038/215193a0. [DOI] [PubMed] [Google Scholar]
  16. Purtilo D. T., Hallgren H. M., Yunis E. J. Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. Lancet. 1972 Apr 8;1(7754):769–771. doi: 10.1016/s0140-6736(72)90522-3. [DOI] [PubMed] [Google Scholar]
  17. Ragab A. H., Hazlett B., Cowan D. H. Response of peripheral blood lymphocytes from patients with diabetes mellitus to phytohemagglutinin and Candida albicans antigen. Diabetes. 1972 Aug;21(8):906–907. doi: 10.2337/diab.21.8.906. [DOI] [PubMed] [Google Scholar]
  18. Revillard J. P., Brochier J. Selective deficiency of cell-mediated immunity in humans treated with antilymphocytes globulins. Transplant Proc. 1971 Mar;3(1):725–729. [PubMed] [Google Scholar]
  19. Revillard J. P. Les cultures de lymphocytes. Pathol Biol (Paris) 1971 Dec;19(23):1089–1098. [PubMed] [Google Scholar]
  20. Richter M., Naspitz C. K. The variation in response of human peripheral lymphocytes to phytohemagglutinin in vitro. Int Arch Allergy Appl Immunol. 1967;32(3):288–293. doi: 10.1159/000229939. [DOI] [PubMed] [Google Scholar]
  21. Robson L. C., Schwarz M. R. The influence of adult thymectomy on immunological competence as measured by the mixed lymphocyte reaction. Transplantation. 1971 May;11(5):465–470. doi: 10.1097/00007890-197105000-00006. [DOI] [PubMed] [Google Scholar]
  22. Rohmann H. Uber die Phagozytose der Leukozyten bei Diabetikern. Folia Haematol Int Mag Klin Morphol Blutforsch. 1966;85(3):267–273. [PubMed] [Google Scholar]
  23. Sengar D. P., Terasaki P. I. A semimicro mixed leukocyte culture test. Transplantation. 1971 Mar;11(3):260–267. doi: 10.1097/00007890-197103000-00004. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES