Abstract
The immunological adjuvant Corynebacterium parvum has been to activate the alternate pathway of complement in human and guinea-pig serum. Human serum in addition contains anti-C. parvum antibodies leading to activation of the classical complement pathway. The possible role of a C. parvum derived polysaccharide in this activation is considered in relation to the biological effects of the micro-organism.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Borsos T., Rapp H. J. Immune hemolysis: a simplified method for the preparation of EAC'4 with guinea pig or with human complement. J Immunol. 1967 Aug;99(2):263–268. [PubMed] [Google Scholar]
- Dukor P., Schumann G., Gisler R. H., Dierich M., König W., Hadding U., Bitter-Suermann D. Complement-dependent B-cell activation by cobra venom factor and other mitogens? J Exp Med. 1974 Feb 1;139(2):337–354. doi: 10.1084/jem.139.2.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Götze O., Müller-Eberhard H. J. The C3-activator system: an alternate pathway of complement activation. J Exp Med. 1971 Sep 1;134(3 Pt 2):90s–108s. [PubMed] [Google Scholar]
- HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
- Halpern B. N., Biozzi G., Stiffel C., Mouton D. Inhibition of tumour growth by administration of killed corynebacterium parvum. Nature. 1966 Nov 19;212(5064):853–854. doi: 10.1038/212853a0. [DOI] [PubMed] [Google Scholar]
- McBride W. H., Jones J. T., Weir D. M. Increased phagocytic cell activity and anaemia in Corynebacterium parvum treated mice. Br J Exp Pathol. 1974 Feb;55(1):38–46. [PMC free article] [PubMed] [Google Scholar]
- McCracken A., McBride W. H., Weir D. M. Adjuvant-induced antired blood cell activity in CBA mice. Clin Exp Immunol. 1971 Jun;8(6):949–955. [PMC free article] [PubMed] [Google Scholar]
- Pepys M. B. Role of complement in induction of the allergic response. Nat New Biol. 1972 May 31;237(74):157–159. doi: 10.1038/newbio237157a0. [DOI] [PubMed] [Google Scholar]
- Woodruff M. F., Boak J. L. Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer. 1966 Jun;20(2):345–355. doi: 10.1038/bjc.1966.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodruff M. F., McBride W. H., Dunbar N. Tumour growth, phagocytic activity and antibody response in Corynebacterium parvum-treated mice. Clin Exp Immunol. 1974 Jul;17(3):509–518. [PMC free article] [PubMed] [Google Scholar]