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. 1980 Feb;39(2):337–343.

Lymphocyte 5'-nucleotidase in primary hypogammaglobulinaemia and cord blood.

M Rowe, G C de Gast, T A Platts-Mills, G L Asherson, A D Webster, S M Johnson
PMCID: PMC1538060  PMID: 6248281

Abstract

The 5'-nucleotidase (5'-N) deficiency on circulating mononuclear cells of patients with 'common variable' hypogammaglobulinaemia (CV-H) was shown to be the result of one or more of three factors: reduced T cell 5'-N activity, a reduced percentage of circulating B cells, and a low B cell 5'-N activity. A lack of circulating B lymphocytes, together with a low T cell 5'-N activity in some cases, was found to be responsible for the deficiency of lymphocyte 5'-N in patients with X-linked hypogammaglobulinaemia (X-H). The low levels of 5'-N activity in CV-H and X-H patients were not due to abnormal compartmentalization of the enzyme, altered enzyme kinetics, or the presence of a regulatory factor. Cord Blood B and T cells have a lower 5'-N activity than adult lymphocytes. The patient and cord blood data are discussed in relation to the stage of cellular maturity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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