Abstract
Mouse RBC (M) rosettes were investigated on lymphocytes from peripheral blood (PB) and various tissues in twenty patients with chronic lymphocytic leukaemia and one with follicular lymphoma. In all cases studied, the percentage of M rosettes was significantly higher in PB (median 64%) than in bone marrow (median 15%) and lymph node (median 12%). These differences were statistically significant (P less than 0.01). The possibility that these differences were related to technical factors was ruled out by a number of control procedures. It is suggested that the different expression of M rosette formation reflects the property which determines whether a lymphocyte enters the peripheral blood or remains fixed in the tissues.
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Selected References
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- Braylan R. C., Jaffe E. S., Burbach J. W., Frank M. M., Johnson R. E., Berard C. W. Similarities of surface characteristics of neoplastic well-differentiated lymphocytes from solid tissues and from peripheral blood. Cancer Res. 1976 May;36(5):1619–1625. [PubMed] [Google Scholar]
- Catovsky D., Cherchi M., Okos A., Hegde U., Galton D. A. Mouse red-cell rosettes in B-lymphoproliferative disorders. Br J Haematol. 1976 Jun;33(2):173–177. doi: 10.1111/j.1365-2141.1976.tb03528.x. [DOI] [PubMed] [Google Scholar]
- Galton D. A., Catovsky D., Wiltshaw E. Clinical spectrum of lymphoproliferative diseases. Cancer. 1978 Aug;42(2 Suppl):901–910. doi: 10.1002/1097-0142(197808)42:2+<901::aid-cncr2820420712>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
- Gupta S., Grieco M. H. Rosette formation with mouse erythrocytes: probable marker for human B lymphocytes. Int Arch Allergy Appl Immunol. 1975;49(6):734–742. doi: 10.1159/000231457. [DOI] [PubMed] [Google Scholar]
- Gupta S., Pahwa R., O'Reilly R., Good R. A., Siegal F. P. Ontogeny of lymphocyte subpopulations in human fetal liver. Proc Natl Acad Sci U S A. 1976 Mar;73(3):919–922. doi: 10.1073/pnas.73.3.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoffman K. D., Rudders R. A. Multiple myeloma and chronic lymphocytic leukemia in a single individual. Arch Intern Med. 1977 Feb;137(2):232–235. doi: 10.1001/archinte.137.2.232. [DOI] [PubMed] [Google Scholar]
- Stathopoulos G., Elliott E. V. Formation of mouse or sheep red-blood-cell rosettes by lymphocytes from normal and leukaemic individuals. Lancet. 1974 Apr 6;1(7858):600–601. doi: 10.1016/s0140-6736(74)92655-5. [DOI] [PubMed] [Google Scholar]
- Wilson A. B., Haegert D. G., Coombs R. R. Increased sensitivity of the rosette-forming reaction of human T lymphocytes with sheep erythrocytes afforded by papain treatment of the sheep cells. Clin Exp Immunol. 1975 Oct;22(1):177–182. [PMC free article] [PubMed] [Google Scholar]
- Wybran J., Chantler S., Fudenberg H. H. Isolation of normal T cells in chronic lymphatic leukaemia. Lancet. 1973 Jan 20;1(7795):126–129. doi: 10.1016/s0140-6736(73)90196-7. [DOI] [PubMed] [Google Scholar]