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. 1980 Feb;39(2):344–348.

Defective membrane function in a patient with severe combined immunodeficiency disease.

R C Gehrz, J J McAuliffe, K M Linner, J H Kersey
PMCID: PMC1538079  PMID: 6771075

Abstract

We report a girl with severe combined immunodeficiency with functional impairment of both humoral and cellular immunity despite normal numbers of B and T lymphocytes. Immunologic studies revealed hypergammaglobulinaemia, absent migratory response by polymorphonuclear leucocytes to chemoattractants, and diminished lymphocyte proliferative responses to mitogens, antigens and allogeneic leucocytes. However, stimulation of the patient's mononuclear leucocytes with the calcium ionophore, A23187, resulted in a normal proliferative response. We therefore postulate a membrane defect as the basis for immunologic dysfunction in this child.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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