Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1975 Feb;19(2):201–208.

Reactive lymphoid cells ('Immunoblasts') in autoimmune and haematological disorders.

P A Bacon, R L Sewell, D Crowther
PMCID: PMC1538089  PMID: 1240046

Abstract

Reactive changes in the lymphoid cells are seen in patients with active rheumatoid arthritis and the degree of reactivity is related to the activity of the disease. The test may be useful as an early indication of relapse in autoimmune disease. Changes are also described in the lymphoid cells of the blood in patients with idiopathic thrombocytopenic purpura, which are identical with those seen in other autoimmune disorders, in infections, and following immunization. This provides supporting evidence for the autoimmune nature of this disease. In contrast with this, patients with aplastic anaemia have been found to have entirely normal lymphoid cell populations in the peripheral blood and provide no evidence that this condition has an autoimmune basis.

Full text

PDF
201

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOND V. P., CRONKITE E. P., FLIEDNER T. M., SCHORK P. Deoxyribonucleic acid synthesizing cells in peripheral blood of normal human beings. Science. 1958 Jul 25;128(3317):202–203. doi: 10.1126/science.128.3317.202. [DOI] [PubMed] [Google Scholar]
  2. Bacon P. A., Cracchiolo A., Bluestone R., Goldberg L. S. Cell-mediated immunity to synovial antigens in rheumatoid arthritis. Lancet. 1973 Sep 29;2(7831):699–702. doi: 10.1016/s0140-6736(73)92537-3. [DOI] [PubMed] [Google Scholar]
  3. COOPER I. A., FIRKIN B. G. DEOXYRIBONUCLEIC ACID SYNTHESIZING CELLS IN THE PERIPHERAL BLOOD OF PATIENTS WITH "AUTO-IMMUNE" DISORDERS. Australas Ann Med. 1965 May;14:142–145. doi: 10.1111/imj.1965.14.2.142. [DOI] [PubMed] [Google Scholar]
  4. Catalona W. J., Taylor P. T., Chretien P. B. Quantitative dinitrochlorobenzene contact sensitization in a normal population. Clin Exp Immunol. 1972 Nov;12(3):325–333. [PMC free article] [PubMed] [Google Scholar]
  5. Coulson A. S., Chalmers D. G. Response of human blood lymphocytes to tuberculin PPD in tissue culture. Immunology. 1967 Apr;12(4):417–429. [PMC free article] [PubMed] [Google Scholar]
  6. Crowther D., Fairley G. H., Sewell R. L. Lymphoid cellular responses in the blood after immunization in man. J Exp Med. 1969 May 1;129(5):849–869. doi: 10.1084/jem.129.5.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GAVOSTO F., PILERI A., MARAINI G. Incorporation of thymidine labelled with tritium by circulating cells of infectious mononucleosis. Nature. 1959 Jun 13;183(4676):1691–1692. doi: 10.1038/1831691a0. [DOI] [PubMed] [Google Scholar]
  8. Gump D. W., Fekety F. R., Jr The relationship of infection and DNA-synthesizing cells in human blood. J Lab Clin Med. 1967 Mar;69(3):428–437. [PubMed] [Google Scholar]
  9. HARRINGTON W. J., MINNICH V., HOLLINGSWORTH J. W., MOORE C. V. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med. 1951 Jul;38(1):1–10. [PubMed] [Google Scholar]
  10. Handin R., Smith A. L. Immunoidiopathic or immunogenic thrombocytopenic purpura. N Engl J Med. 1972 Mar 30;286(13):720–721. doi: 10.1056/NEJM197203302861309. [DOI] [PubMed] [Google Scholar]
  11. Herman J. H., Bradley J., Ziff M., Smiley J. D. Response of the rheumatoid synovial membrane to exogenous immunization. J Clin Invest. 1971 Feb;50(2):266–273. doi: 10.1172/JCI106491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Karpatkin S., Siskind G. W. In vitro detection of platelet antibody in patients with idiopathic thrombocytopenic purpura and systemic lupus erythematosus. Blood. 1969 Jun;33(6):795–812. [PubMed] [Google Scholar]
  13. LaPolla J. J., Thurmon T. F., 3rd Lymphocyte transformation in autoimmune disorders: a preliminary study. J Pediatr. 1966 Dec;69(6):1129–1131. doi: 10.1016/s0022-3476(66)80306-2. [DOI] [PubMed] [Google Scholar]
  14. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  15. SCOTT J. L., CARTWRIGHT G. E., WINTROBE M. M. Acquired aplastic anemia: an analysis of thirty-nine cases and review of the pertinent literature. Medicine (Baltimore) 1959 May;38(2):119–172. [PubMed] [Google Scholar]
  16. Spriggs A. I., Jerrome D. W. Electron-microscopy of Türk cells. Br J Haematol. 1967 Sep;13(5):764–767. doi: 10.1111/j.1365-2141.1967.tb08842.x. [DOI] [PubMed] [Google Scholar]
  17. Williams R. C., Jr, DeBoard J. R., Mellbye O. J., Messner R. P., Lindström F. D. Studies of T- and B-lymphocytes in patients with connective tissue diseases. J Clin Invest. 1973 Feb;52(2):283–295. doi: 10.1172/JCI107184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wood T. A., Frenkel E. P. The atypical lymphocyte. Am J Med. 1967 Jun;42(6):923–936. doi: 10.1016/0002-9343(67)90073-3. [DOI] [PubMed] [Google Scholar]
  19. Wybran J., Fudenberg H. H. Cellular immunity to platelets in idiopathic thrombocytopenic purpura. Blood. 1972 Dec;40(6):856–861. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES