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. 1980 Mar;39(3):676–682.

In vitro studies of the normal human B lymphocyte receptors for preformed soluble dengue antigen-antibody complexes.

S Boonpucknavig, J Siripont
PMCID: PMC1538136  PMID: 6991174

Abstract

Preformed soluble dengue antigen-antibody with or without complement complexes could bind to the surface of human lymphocytes via IgG (Fc) or complement receptors respectively. It may be that these lymphocytes were B lymphocytes not T lymphocytes. Dengue antigen or antibody alone will not attach to the surface of those cells. It is emphasized that dengue antigen-antibody complexes can form in the circulation and some will bind to the surface of the B lymphocytes in vivo and play a significant role in the pathogenesis of dengue haemorrhagic fever. In addition mice could develop glomerulonephritis by injection with preformed soluble dengue antigen-antibody complexes. These mice showed proteinuria and deposits of the immune complexes in the glomeruli of the kidneys.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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