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. 1980 Mar;39(3):588–592.

Studies of lymphocytotoxins in infectious mononucleosis: reduced lymphocyte killing in the acute phase.

J W Quin, J A Charlesworth, C H Lee, G J Macdonald
PMCID: PMC1538144  PMID: 6966547

Abstract

Fifty sera from twenty-five patients with uncomplicated infectious mononucleosis (IM) were tested for lymphocytotoxic activity (LCA) against pools of lymphocytes collected from (a) normal donors (b) ten patients during the acute phase of IM and (c) four of these patients during the convalescent phase. The LCA of twenty-four sera from patients with systemic lupus erythematosus (SLE) was also tested against the same panels of cells. The percentage of acute phase lymphocytes killed by sera from patients with IM or SLE was significantly less (P less than 0.001 and P less than 0.05 respectively) than the percentage of normal or convalescent cells killed by the same sera. This reduction could not be explained by lymphocyte donor variation as the same donors were used in the acute and convalescent phases of IM. It is suggested that changes in the surface characteristics of acute IM lymphocytes cause a temporary failure of interaction with circulating lymphocytotoxins. Such a phenomenon could have important influences on the self-limiting nature of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Charlesworth J. A., Quin J. W., Macdonald G. J., Lennane R. J., Boughton C. R. Complement, lymphocytotoxins and immune complexes in infectious mononucleosis: serial studies in uncomplicated cases. Clin Exp Immunol. 1978 Nov;34(2):241–247. [PMC free article] [PubMed] [Google Scholar]
  2. Haynes B. F., Schooley R. T., Grouse J. E., Payling-Wright C. R., Dolin R., Fauci A. S. Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis. J Immunol. 1979 Feb;122(2):699–702. [PubMed] [Google Scholar]
  3. Huang S. W., Lattos D. B., Nelson D. B., Reeb K., Hong R. Antibody-associated lymphotoxin in acute infection. J Clin Invest. 1973 May;52(5):1033–1040. doi: 10.1172/JCI107268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jondal M., Klein G. Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes. J Exp Med. 1973 Dec 1;138(6):1365–1378. doi: 10.1084/jem.138.6.1365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Loor F., Forni L., Pernis B. The dynamic state of the lymphocyte membrane. Factors affecting the distribution and turnover of surface immunoglobulins. Eur J Immunol. 1972 Jun;2(3):203–212. doi: 10.1002/eji.1830020304. [DOI] [PubMed] [Google Scholar]
  6. McKenna R. W., Parkin J., Gajl-Peczalska K. J., Kersey J. H., Brunning R. D. Ultrastructural, cytochemical, and membrane surface marker characteristics of the atypical lymphocytes in infectious mononucleosis. Blood. 1977 Sep;50(3):505–515. [PubMed] [Google Scholar]
  7. Mittal K. K., Rossen R. D., Sharp J. T., Lidsky M. D., Butler W. T. Lymphocyte cytotoxic antibodies in systemic lupus erythematosus. Nature. 1970 Mar 28;225(5239):1255–1256. doi: 10.1038/2251255a0. [DOI] [PubMed] [Google Scholar]
  8. Moretta L., Mingari M. C., Romanzi C. A. Loss of Fc receptors for IgG from human T lymphocytes exposed to IgG immune complexes. Nature. 1978 Apr 13;272(5654):618–620. doi: 10.1038/272618a0. [DOI] [PubMed] [Google Scholar]
  9. Quin J. W., Charlesworth J. A., Bowman C., Macdonald G. J. Studies of lymphocytotoxins in infectious mononucleosis and systemic lupus erythematosus: evidence for immune complex-mediated cytotoxicity. Clin Exp Immunol. 1980 Mar;39(3):593–598. [PMC free article] [PubMed] [Google Scholar]
  10. Sheldon P. J., Hemsted E. H., Papamichail M., Holborow E. J. Thymic origin of atypical lymphoid cells in infectious mononucleosis. Lancet. 1973 May 26;1(7813):1153–1155. doi: 10.1016/s0140-6736(73)91148-3. [DOI] [PubMed] [Google Scholar]
  11. Svedmyr E., Jondal M. Cytotoxic effector cells specific for B Cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1622–1626. doi: 10.1073/pnas.72.4.1622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. de Petris S., Raff M. C. Distribution of immunoglobulin on the surface of mouse lymphoid cells as determined by immunoferritin electron microscopy. Antibody-induced, temperature-dependent redistribution and its implications for membrane structure. Eur J Immunol. 1972 Dec;2(6):523–535. doi: 10.1002/eji.1830020611. [DOI] [PubMed] [Google Scholar]

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