Abstract
A sheep lymphocyte 125I-labelled human encephalitogenic basic protein (125I-BP) binding assay was used to study the correlation of 125I-BP binding with the diagnosis and status of multiple sclerosis (MS) patients. MS serum generally caused significant inhibition of binding, and serum from MS patients in remission caused significantly more inhibition than serum from MS patients in relapse. Serum inhibition increased in association with improvement in neurological status in three out of four MS patients studied for more than 10 months.
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Selected References
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- Barton M. A., McPherson T. A., Martin J. K. Purification of fully active human encephalitogenic basic protein on sulfoethyl-sephadex. Can J Biochem. 1972 Jun;50(6):684–688. doi: 10.1139/o72-093. [DOI] [PubMed] [Google Scholar]
- Hellström K. E., Hellström I. Immunological enhancement as studied by cell culture techniques. Annu Rev Microbiol. 1970;24:373–398. doi: 10.1146/annurev.mi.24.100170.002105. [DOI] [PubMed] [Google Scholar]
- Hughes D., Caspary E. A., Field E. J. Lymphocyte trnsformation induced by encephalitogenic factor in multiple sclerosis and other neurological diseases. Lancet. 1968 Dec 7;2(7580):1205–1207. doi: 10.1016/s0140-6736(68)91690-5. [DOI] [PubMed] [Google Scholar]
- Kabat E. A., Moore D. H., Landow H. AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS. J Clin Invest. 1942 Sep;21(5):571–577. doi: 10.1172/JCI101335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McPherson T. A., Gilpin A., Seland T. P. Radioimmunoassay of CSF for encephalitogenic basic protein: a diagnostic test for MS? Can Med Assoc J. 1972 Nov 4;107(9):856–859. [PMC free article] [PubMed] [Google Scholar]
- McPherson T. A., Marchalonis J. J., Lennon V. Binding of encephalitogenic basic protein by serum alpha-globulins. Immunology. 1970 Dec;19(6):929–933. [PMC free article] [PubMed] [Google Scholar]
- Morariu M., Böhm T. Delayed dermal hypersensitivity to autologous lymphocytes in multiple sclerosis. Neurology. 1973 Aug;23(8):808–811. doi: 10.1212/wnl.23.8.808. [DOI] [PubMed] [Google Scholar]
- Olsson J. E., Link H. Immunoglobulin abnormalities in multiple sclerosis. Relation to clinical parameters: exacerbations and remissions. Arch Neurol. 1973 Jun;28(6):392–399. doi: 10.1001/archneur.1973.00490240052009. [DOI] [PubMed] [Google Scholar]
- Phillips S. M., Wegmann T. G. Active suppression as a possible mechanism of tolerance in tetraparental mice. J Exp Med. 1973 Feb 1;137(2):291–300. doi: 10.1084/jem.137.2.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seland T. P., Mc Pherson T. A., Grace M., Lamoureux G., Blain J. G. Evaluation of antithymocyte globulin in acute relapses of multiple sclerosis. Neurology. 1974 Jan;24(1):34–40. doi: 10.1212/wnl.24.1.34. [DOI] [PubMed] [Google Scholar]
- Van den Noort S., Stjernholm R. L. Lymphotoxic activity in multiple sclerosis serum. Neurology. 1971 Aug;21(8):783–793. doi: 10.1212/wnl.21.8.783. [DOI] [PubMed] [Google Scholar]
- Vandenbark A. A., Gibbins B. L., Hinrichs D. J. Immunosuppressive activity of serum during the development of experimental allergic encephalomyelitis. Cell Immunol. 1974 Mar 30;11(1-3):1–10. doi: 10.1016/0008-8749(74)90001-x. [DOI] [PubMed] [Google Scholar]
- Yung L. L., Diener E., McPherson T. A., Barton M. A., Hyde H. A. Antigen-binding lymphocytes in normal man and guinea pig to human encephalitogenic protein. J Immunol. 1973 May;110(5):1383–1387. [PubMed] [Google Scholar]
