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. 1975 Mar;19(3):533–542.

Effect of age on cell-mediated immunity in long-lived mice.

S A Goodman, T Makinodan
PMCID: PMC1538163  PMID: 812622

Abstract

The cytolytic ability of sensitized spleen cells to kill allogeneic target cells in vitro, a correlate of cell-mediated immune activity, was assessed in aging long-lived hybrid mice. There was about a 4-fold decline with age, of which about 2-fold could be accounted for by the decrease in relative numbers of immunocompetent precursor cell units. The terminally differentiated progeny cells of antigen-stimulated precursor cells of old mice were as efficient in killing target cells as were those of precursor cells of young mice. Thus, it would appear that a decrease in the proliferative and transforming capacities of antigen-stimulated precursor cells of old mice can account for the other 2-fold decline with age in the cytolytic activity. Cytolytic activity may not be the limiting function in resistance to tumour formation. This was indicated by the observation that resistance to allogeneic tumor cell challenge declines with age by as much as 500-fold in mice, showing only a 4-fold decline in their cytolytic activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albright J. F., Makinodan T. Growth and senescence of antibody-forming cells. J Cell Physiol. 1966 Jun;67(3 Suppl):185+–185+. doi: 10.1002/jcp.1040670415. [DOI] [PubMed] [Google Scholar]
  2. Bosma M. J., Makinodan T., Walburg H. E., Jr Development of immunologic competence in germfree and conventional mice. J Immunol. 1967 Aug;99(2):420–430. [PubMed] [Google Scholar]
  3. Bosma M. J., Perkins E. H., Makinodan T. Further characterization of the lymphoid cell transfer system for the study of antigen-sensitive progenitor cells. J Immunol. 1968 Nov;101(5):963–972. [PubMed] [Google Scholar]
  4. Brunner K. T., Mauel J., Rudolf H., Chapuis B. Studies of allograft immunity in mice. I. Induction, development and in vitro assay of cellular immunity. Immunology. 1970 Apr;18(4):501–515. [PMC free article] [PubMed] [Google Scholar]
  5. Burnet F. M. The concept of immunological surveillance. Prog Exp Tumor Res. 1970;13:1–27. doi: 10.1159/000386035. [DOI] [PubMed] [Google Scholar]
  6. COLE L. J. Ageing at the cellular level. Differential effect of transplanted isogenic lymphoid cells from old versus young mice. Gerontologia. 1962;6:36–40. doi: 10.1159/000211104. [DOI] [PubMed] [Google Scholar]
  7. Cerottini J. C., Nordin A. A., Brunner K. T. Cellular and humoral response to transplantation antigens. I. Development of alloantibody-forming cells and cytotoxic lymphocytes in the graft-versus-host reaction. J Exp Med. 1971 Aug 1;134(2):553–564. doi: 10.1084/jem.134.2.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chen M. G., Price G. B., Makinodan T. Incidence of delayed mortality (secondary disease) in allogeneic radiation chimeras receiving bone marrow from aged mice. J Immunol. 1972 May;108(5):1370–1378. [PubMed] [Google Scholar]
  9. Chino F., Makinodan T., Lever W. E., Peterson W. J. The immune systems of mice reared in clean and in dirty conventional laboratory farms. I. Life expectancy and pathology of mice with long life-spans. J Gerontol. 1971 Oct;26(4):497–507. doi: 10.1093/geronj/26.4.497. [DOI] [PubMed] [Google Scholar]
  10. Davis W. E., Jr, Cole L. J. Homograft response in adult-thymectomized mice: deficiency with aging and after low dose-rate gamma-irradiation. Exp Gerontol. 1968 Mar;3(1):9–17. doi: 10.1016/0531-5565(68)90051-x. [DOI] [PubMed] [Google Scholar]
  11. Gazdar A. F., Beitzel W., Talal N. The age related responses of New Zealand mice to a murine sarcoma virus. Clin Exp Immunol. 1971 Mar;8(3):501–509. [PMC free article] [PubMed] [Google Scholar]
  12. Groves D. L., Lever W. E., Makinodan T. A model for the interaction of cell types in the generation of hemolytic plaque-forming cells. J Immunol. 1970 Jan;104(1):148–165. [PubMed] [Google Scholar]
  13. Halsall M. K., Makinodan T. Analysis of the limiting-dilution assay used for estimating frequencies of immunocompetent units. Cell Immunol. 1974 Mar 30;11(1-3):456–465. doi: 10.1016/0008-8749(74)90043-4. [DOI] [PubMed] [Google Scholar]
  14. Hargis B. J., Malkiel S. The immunocapacity of the AKR mouse. Cancer Res. 1972 Feb;32(2):291–297. [PubMed] [Google Scholar]
  15. Henney C. S. Quantitation of the cell-mediated immune response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogeneic mastocytoma cells. J Immunol. 1971 Dec;107(6):1558–1566. [PubMed] [Google Scholar]
  16. KROHN P. L. The vigour of the homograft reaction in old mice. Gerontologia. 1961;5:182–185. doi: 10.1159/000211055. [DOI] [PubMed] [Google Scholar]
  17. Konen T. G., Smith G. S., Walford R. L. Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain. J Immunol. 1973 May;110(5):1216–1221. [PubMed] [Google Scholar]
  18. Makinodan T., Chino F., Lever W. E., Brewen B. S. The immune systems of mice reared in clean and in dirty conventional laboratory farms. 3. Ability of old mice to be sensitized to undergo a secondary antibody response. J Gerontol. 1971 Oct;26(4):515–520. doi: 10.1093/geronj/26.4.515. [DOI] [PubMed] [Google Scholar]
  19. Makinodan T., Chino F., Lever W. E., Brewen B. S. The immune systems of mice reared in clean and in dirty conventional laboratory farms. II. Primary antibody-forming activity of young and old mice with long life-spans. J Gerontol. 1971 Oct;26(4):508–514. doi: 10.1093/geronj/26.4.508. [DOI] [PubMed] [Google Scholar]
  20. Makinodan T., Perkins E. H., Chen M. G. Immunologicc activity of the aged. Adv Gerontol Res. 1971;3:171–198. [PubMed] [Google Scholar]
  21. Price G. B., Makinodan T. Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies. J Immunol. 1972 Feb;108(2):403–412. [PubMed] [Google Scholar]
  22. Price G. B., Makinodan T. Immunologic deficiencies in senescence. II. Characterization of extrinsic deficiencies. J Immunol. 1972 Feb;108(2):413–417. [PubMed] [Google Scholar]
  23. Stjernswärd J. Age-dependent tumor-host barrier and effect of carcinogen-induced immunodepression on rejection of isografted methylcholanthrene-induced sarcoma cells. J Natl Cancer Inst. 1966 Oct;37(4):505–512. [PubMed] [Google Scholar]
  24. Stutman O., Yunis E. J., Good R. A. Deficient immunologic functions of NZB mice. Proc Soc Exp Biol Med. 1968 Apr;127(4):1204–1207. doi: 10.3181/00379727-127-32910. [DOI] [PubMed] [Google Scholar]
  25. TELLER M. N., CURLETT W., KUBISEK M. L., CURTIS D., STOHR G. AGING AND CANCERIGENESIS. I. IMMUNITY TO TUMOR AND SKIN GRAFTS. J Natl Cancer Inst. 1964 Oct;33:649–656. [PubMed] [Google Scholar]
  26. Teague P. O., Yunis E. J., Rodey G., Fish A. J., Stutman O., Good R. A. Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity. Lab Invest. 1970 Feb;22(2):121–130. [PubMed] [Google Scholar]

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