Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1975 May;20(2):187–192.

Reduced antibody-dependent cell-mediated cytotoxicity in systemic lupus erythematosus.

J Schneider, W Chin, G J Friou, S M Cooper, B Harding, R L Hill, F P Quismorio
PMCID: PMC1538206  PMID: 1212807

Abstract

The peripheral blood mononuclear cells from twenty-three patients with SLE were studied. They showed a reduction in antibody-dependent cell-mediated cytotoxicity. This reduction was significantly related to disease activity. No correlations were found with other clinical features. Some of the possible explanations for this finding are discussed.

Full text

PDF
187

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnett I. G., MacLennan I. C. Inhibitory effect of rheumatoid sera on cell damage by lymphocytes. Ann Rheum Dis. 1972 Sep;31(5):425–425. doi: 10.1136/ard.31.5.425-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Calder E. A., Penhale W. J., McLeman D., Barnes E. W., Irvine W. J. Lymphocyte-dependent antibody-mediated cytotoxicity in Hashimoto thyroiditis. Clin Exp Immunol. 1973 Jun;14(2):153–158. [PMC free article] [PubMed] [Google Scholar]
  3. Campbell A. C., Hersey P., MacLennan I. C., Kay H. E., Pike M. C. Immunosuppressive consequences of radiotherapy and chemotherapy in patients with acute lymphoblastic leukaemia. Br Med J. 1973 May 19;2(5863):385–388. doi: 10.1136/bmj.2.5863.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Campbell A. C., Maclennan I. C., Snaith M. L., Barnett I. G. Selective deficiency of cytotoxic B lymphocytes in man. Clin Exp Immunol. 1972 Sep;12(1):1–8. [PMC free article] [PubMed] [Google Scholar]
  5. Campbell A. C., Skinner J. M., Hersey P., Roberts-Thomson P., MacLennan I. C., Truelove S. C. Immunosuppression in the treatment of inflammatory bowel disease. I. Changes in lymphoid sub-populations in the blood and rectal mucosa following cessation of treatment with azathioprine. Clin Exp Immunol. 1974 Apr;16(4):521–533. [PMC free article] [PubMed] [Google Scholar]
  6. Forman J., Möller G. The effector cell in antibody-induced cell mediated immunity. Transplant Rev. 1973;17(0):108–149. doi: 10.1111/j.1600-065x.1973.tb00125.x. [DOI] [PubMed] [Google Scholar]
  7. Greenberg A. H., Playfair J. H. Spontaneously arising cytotoxicity to the P-815-Y mastocytoma in NZB mice. Clin Exp Immunol. 1974 Jan;16(1):99–109. [PMC free article] [PubMed] [Google Scholar]
  8. Hallberg T. In vitro cytotoxicity of human lymphocytes for sensitized chicken erythrocytes is inhibited by sera from rheumatoid arthritis patients. Scand J Immunol. 1972;1(4):329–338. doi: 10.1111/j.1365-3083.1972.tb03298.x. [DOI] [PubMed] [Google Scholar]
  9. Harbeck R. J., Bardana E. J., Kohler P. F., Carr R. I. DNA:anti-DNA complexes: their detection in systemic lupus erythematosus sera. J Clin Invest. 1973 Apr;52(4):789–795. doi: 10.1172/JCI107242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Harding B., MacLennan I. C. The distribution of antibody and antibody-producing cells after immunization with xenogeneic cells. Immunology. 1972 Jul;23(1):35–43. [PMC free article] [PubMed] [Google Scholar]
  11. Hersey P., Cullen P., MacLennan I. C. Lymphocyte-dependent cytotoxic antibody activity against human transplantation antigens. Transplantation. 1973 Jul;16(1):9–16. doi: 10.1097/00007890-197307000-00003. [DOI] [PubMed] [Google Scholar]
  12. Holm G., Perlmann P. Quantitative studies on phytohaemagglutinin-induced cytotoxicity by human lymphocytes against homologous cells in tissue culture. Immunology. 1967 May;12(5):525–536. [PMC free article] [PubMed] [Google Scholar]
  13. Jewell D. P., MacLennan I. C. Circulating immune complexes in inflammatory bowel disease. Clin Exp Immunol. 1973 Jun;14(2):219–226. [PMC free article] [PubMed] [Google Scholar]
  14. Lies R. B., Messner R. P., Williams R. C., Jr Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum. 1973 May-Jun;16(3):369–375. doi: 10.1002/art.1780160312. [DOI] [PubMed] [Google Scholar]
  15. MOELLER E. CONTACT-INDUCED CYTOTOXICITY BY LYMPHOID CELLS CONTAINING FOREIGN ISOANTIGENS. Science. 1965 Feb 19;147(3660):873–879. doi: 10.1126/science.147.3660.873. [DOI] [PubMed] [Google Scholar]
  16. MacLennan I. C. Competition for receptors for immunoglobulin on cytotoxic lymphocytes. Clin Exp Immunol. 1972 Feb;10(2):275–283. [PMC free article] [PubMed] [Google Scholar]
  17. Mellstedt H., Jondal M., Holm G. In vitro studies of lymphocytes from patients with plasma cell myeloma. II. Characterization by cell surface markers. Clin Exp Immunol. 1973 Nov;15(3):321–330. [PMC free article] [PubMed] [Google Scholar]
  18. O'Toole C., Stejskal V., Perlmann P., Karlsson M. Lymphoid cells mediating tumor-specific cytotoxicity to carcinoma of the urinary bladder. Separation of the effector population using a surface marker. J Exp Med. 1974 Mar 1;139(3):457–466. doi: 10.1084/jem.139.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Perlmann P., Perlmann H. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes. Cell Immunol. 1970 Sep;1(3):300–315. doi: 10.1016/0008-8749(70)90051-1. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES