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. 1975 Aug;21(2):216–225.

Observations on the antibody-dependent cytotoxic cell by scanning electron microscopy.

J R Inglis, W J Penhale, A Farmer, W J Irvine, A E Williams
PMCID: PMC1538261  PMID: 1191386

Abstract

The cytotoxic effect of human peripheral blood leucocytes on antibody-coated sheep erythrocyte monolayers has been investigated using scanning electron microscopy. Only a small proportion of leucocytes were found to adhere to the monolayers. A progressive destruction was observed beginning as small plaque-like areas of erythrocyte clearing which later became confluent. Three distinct cell types were found to be associated with the areas of lysis. No destruction was observed in control monolayers incubated for a similar period in the absence of either antibody of leucocytes. Surface changes in the erthrocytes adjacent to the leucocytes suggest that mechanical factors may be involved in erythrocyte lysis in this system. It is concluded that more than one leucocyte type may damage antibody-coated erythrocytes, possibly by a mechanism involving attachment to and mechanical disruption of the red cell membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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