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. 1975 Nov;22(2):210–222.

Human faecal immunoglobulins in healthy infants and children, and in some with diseases affecting the intestinal tract or the immune system.

B Haneberg, D Aarskog
PMCID: PMC1538294  PMID: 813931

Abstract

IgA, IgG and IgM is faeces were quantified by single radial immunodiffusion using extracts of freeze-dried faeces. IgA in small specimens of faeces seemed to mirror the total amound of IgA secreted into the gut at the time of sampling. Presumptive normal values of faecal IgA concentrations in infants and children were established. Agglutinins to rabbit erythrocytes served as markers for the antibody activity. Infants and children just recovered from enteritis of probably infectious origin had higher concentrations of both IgA and agglutinins in faeces. Faeces from three out of five patients with ulcerative colitis in remission, contained IgG in markedly increased concentrations. Two patients with IgA deficiency had no detectable IgA in faeces, but had increased levels of faecal IgM which also agglutinated rabbit erythrocytes. Immunoglobulins were not demonstrated in faeces from three patients with agammaglobulinaemia. The findings indicate that faeces can be used for assay of immunoglobulins of the intestinal tract.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agus S. G., Falchuk Z. M., Sessoms C. S., Wyatt R. G., Dolin R. Increased jejunal IgA synthesis in vitro during acute infectious nonbacterial gastroenteritis. Am J Dig Dis. 1974 Feb;19(2):127–131. doi: 10.1007/BF01072622. [DOI] [PubMed] [Google Scholar]
  2. Brandtzaeg P., Baklien K., Fausa O., Hoel P. S. Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology. 1974 Jun;66(6):1123–1136. [PubMed] [Google Scholar]
  3. Brandtzaeg P., Fjellanger I., Gjeruldsen S. T. Immunoglobulin M: local synthesis and selective secretion in patients with immunoglobulin A deficiency. Science. 1968 May 17;160(3829):789–791. doi: 10.1126/science.160.3829.789. [DOI] [PubMed] [Google Scholar]
  4. Crabbé P. A., Heremans J. F. Lack of gamma A-immunoglobulin in serum of patients with steatorrhoea. Gut. 1966 Apr;7(2):119–127. doi: 10.1136/gut.7.2.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FRETER R., DE S. P., MONDAL A., SHRIVASTAVA D. L., SUNDERMAN F. W., Jr COPROANTIBODY AND SERUM ANTIBODY IN CHOLERA PATIENTS. J Infect Dis. 1965 Feb;115:83–87. doi: 10.1093/infdis/115.1.83. [DOI] [PubMed] [Google Scholar]
  6. Gelzayd E. A., Kraft S. C., Fitch F. W., Kirsner J. B. Distribution of immunoglobulins in human rectal mucosa. II. Ulcerative colitis and abnormal mucosal control subjects. Gastroenterology. 1968 Mar;54(3):341–347. [PubMed] [Google Scholar]
  7. Haneberg B. Human fetal agglutinins to rabbit erythrocytes. Scand J Immunol. 1974;3(1):71–76. doi: 10.1111/j.1365-3083.1974.tb01234.x. [DOI] [PubMed] [Google Scholar]
  8. Haneberg B. Human milk immunoglobulins and agglutinins to rabbit erythrocytes. Int Arch Allergy Appl Immunol. 1974;47(5):716–729. doi: 10.1159/000231263. [DOI] [PubMed] [Google Scholar]
  9. Haneberg B. Immunoglobulins in feces from infants fed human or bovine milk. Scand J Immunol. 1974;3(2):191–197. doi: 10.1111/j.1365-3083.1974.tb01247.x. [DOI] [PubMed] [Google Scholar]
  10. Haneberg B., Tonder O. Immunoglobulins and other serum proteins in feces from infants and children. Scand J Immunol. 1973;2(4):375–383. doi: 10.1111/j.1365-3083.1973.tb02046.x. [DOI] [PubMed] [Google Scholar]
  11. Panayotou P., Papadatos C., Papaevangelou G., Alexiou D., Skardoutsou A., Kourea E. Immunoglobulin A and M levels in premature infants with gastroenteritis. Arch Dis Child. 1971 Oct;46(249):671–675. doi: 10.1136/adc.46.249.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. ROULET D. L., von MURALT [Antigen analytic research on amniotic fluid and meconium proteins. Contribution to the problem of immune globulin transmission from mother to child]. Schweiz Med Wochenschr. 1961 Jan 21;91:74–79. [PubMed] [Google Scholar]
  13. Reed W. P., Williams R. C., Jr Intestinal immunoglobulins in shigellosis. Gastroenterology. 1971 Jul;61(1):35–45. [PubMed] [Google Scholar]
  14. Rule A. H., Lawrence D., Hager H. J., Hyslop N., Jr, Shwachman H. IgA: presence in meconium obtained from patients with cystic fibrosis. Pediatrics. 1971 Oct;48(4):601–604. [PubMed] [Google Scholar]
  15. Samson R. R., McClelland D. B., Shearman D. J. Studies on the quantitation of immunoglobulin in human intestinal secretions. Gut. 1973 Aug;14(8):616–626. doi: 10.1136/gut.14.8.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Savilahti E. IgA deficiency in children. Immunoglobulin-containing cells in the intestinal mucosa, immunoglobulins in secretions and serum IgA levels. Clin Exp Immunol. 1973 Mar;13(3):395–406. [PMC free article] [PubMed] [Google Scholar]
  17. Shearman D. J., Parkin D. M., McClelland D. B. The demonstration and function of antibodies in the gastrointestinal tract. Gut. 1972 Jun;13(6):483–499. doi: 10.1136/gut.13.6.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. South M. A., Copper M. D., Wollheim F. A., Good R. A. The IgA system. II. The clinical significance of IgA deficiency: studies in patients with agammaglobulinemia and ataxia-telangiectasia. Am J Med. 1968 Feb;44(2):168–178. doi: 10.1016/0002-9343(68)90148-4. [DOI] [PubMed] [Google Scholar]
  19. Tomasi T. B., Grey H. M. Structure and function of immunoglobulin A. Prog Allergy. 1972;16:81–213. [PubMed] [Google Scholar]

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