Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1975 Oct;22(1):47–53.

HL-A3 and HL-A7 in pernicious anaemia and autoimmune atrophic gastritis.

H Mawhinney, J W Lawton, A G White, W J Irvine
PMCID: PMC1538348  PMID: 1212816

Abstract

Increased frequencies of HL-A7 and the HL-A3,7 haplotype have been demonstrated in pernicious anaemia. There was no significant increase in any HL-A specificity in autoimmune atrophic gastritis. In the whole series of patients with either pernicious anaemia or atrophic gastritis there was a significant increase in the frequency of HL-A3. No association has been found between any HL-A specificity and an increased incidence of either serum gastric parietal cell or intrinsic factor antibody compared with the overall incidence in pernicious anaemia, atrophic gastritis or in the whole series.

Full text

PDF
47

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bottazzo G. F., Florin-Christensen A., Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974 Nov 30;2(7892):1279–1283. doi: 10.1016/s0140-6736(74)90140-8. [DOI] [PubMed] [Google Scholar]
  2. CALLENDER S. T., SPRAY G. H. Latent pernicious anaemia. Br J Haematol. 1962 Jul;8:230–240. doi: 10.1111/j.1365-2141.1962.tb06516.x. [DOI] [PubMed] [Google Scholar]
  3. FISHER J. M., TAYLOR K. B. A COMPARISON OF AUTOIMMUNE PHENOMENA IN PERNICIOUS ANEMIA AND CHRONIC ATROPHIC GASTRITIS. N Engl J Med. 1965 Mar 11;272:499–503. doi: 10.1056/NEJM196503112721002. [DOI] [PubMed] [Google Scholar]
  4. Feltkamp T. E., van den Berg-Loonen P. M., Nijenhuis L. E., Engelfriet C. P., van Rossum A. L., van Loghem J. J., Oosterhuis H. J. Myasthenia gravis, autoantibodies, and HL-A antigens. Br Med J. 1974 Jan 26;1(5899):131–133. doi: 10.1136/bmj.1.5899.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. IRVINE W. J. GASTRIC ANTIBODIES STUDIED BY FLUORESCENCE MICROSCOPY. Q J Exp Physiol Cogn Med Sci. 1963 Oct;48:427–438. doi: 10.1113/expphysiol.1963.sp001685. [DOI] [PubMed] [Google Scholar]
  6. IRVINE W. J. IMMUNOLOGIC ASPECTS OF PERNICIOUS ANEMIA. N Engl J Med. 1965 Aug 19;273:432–438. doi: 10.1056/NEJM196508192730807. [DOI] [PubMed] [Google Scholar]
  7. Irvine W. J., Cullen D. R., Mawhinney H. Natural history of autoimmune achlorhydric atrophic gastritis. A 1-15-year follow-up study. Lancet. 1974 Aug 31;2(7879):482–485. doi: 10.1016/s0140-6736(74)92013-3. [DOI] [PubMed] [Google Scholar]
  8. Irvine W. J., Cullen D. R., Scarth L., Simpson J. D., Davies S. H. Total body counting in the assessment of vitamin B12 absorption in patients with pernicious anemia, achlorhydria without pernicious anemia and in acid secretors. Blood. 1970 Jul;36(1):20–27. [PubMed] [Google Scholar]
  9. Irvine W. J. Immunoassay of gastric intrinsic factor and the titration of antibody to intrinsic factor. Clin Exp Immunol. 1966 Jan;1(1):99–118. [PMC free article] [PubMed] [Google Scholar]
  10. Jersild C., Ammitzboll T., Clausen J., Fog T. Association between HL-A antigens and measles antibody in multiple sclerosis. Lancet. 1973 Jan 20;1(7795):151–152. doi: 10.1016/s0140-6736(73)90224-9. [DOI] [PubMed] [Google Scholar]
  11. MacCuish A. C., Irvine W. J., Barnes E. W., Duncan L. J. Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. Lancet. 1974 Dec 28;2(7896):1529–1531. doi: 10.1016/s0140-6736(74)90281-5. [DOI] [PubMed] [Google Scholar]
  12. McDevitt H. O., Bodmer W. F. HL-A, immune-response genes, and disease. Lancet. 1974 Jun 22;1(7869):1269–1275. doi: 10.1016/s0140-6736(74)90021-x. [DOI] [PubMed] [Google Scholar]
  13. Nerup J., Platz P., Andersen O. O., Christy M., Lyngsoe J., Poulsen J. E., Ryder L. P., Nielsen L. S., Thomsen M., Svejgaard A. HL-A antigens and diabetes mellitus. Lancet. 1974 Oct 12;2(7885):864–866. doi: 10.1016/s0140-6736(74)91201-x. [DOI] [PubMed] [Google Scholar]
  14. Pietsch M. C., Morris P. J. An association of HL-A3 and HL-A7 with paralytic poliomyelitis. Tissue Antigens. 1974;4(1):50–55. doi: 10.1111/j.1399-0039.1974.tb00224.x. [DOI] [PubMed] [Google Scholar]
  15. Platz P., Ryder L., Nielsen L. S., Svejgaard A., Thomsen M., Nerup J., Christy M. Letter: HL-A and idiopathic Addison's disease. Lancet. 1974 Aug 3;2(7875):289–289. doi: 10.1016/s0140-6736(74)91450-0. [DOI] [PubMed] [Google Scholar]
  16. Scott B. B., Swinburne M. L., Rajah S. M., Losowsky M. S. HL-As and the immune response to gluten. Lancet. 1974 Aug 17;2(7877):374–377. doi: 10.1016/s0140-6736(74)91758-9. [DOI] [PubMed] [Google Scholar]
  17. Stokes P. L., Asquith P., Holmes G. K., Mackintosh P., Cooke W. T. Histocompatibility antigens associated with adult coeliac disease. Lancet. 1972 Jul 22;2(7769):162–164. doi: 10.1016/s0140-6736(72)91330-x. [DOI] [PubMed] [Google Scholar]
  18. Strickland R. G., Mackay I. R. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis. 1973 May;18(5):426–440. doi: 10.1007/BF01071995. [DOI] [PubMed] [Google Scholar]
  19. Vladutiu A. O., Rose N. R. Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science. 1971 Dec 10;174(4014):1137–1139. doi: 10.1126/science.174.4014.1137. [DOI] [PubMed] [Google Scholar]
  20. White A. G., Barnetson R. S., Da Costa J. A., McClelland D. B. The incidence of HL-A antigens in dermatitis herpetiformis. Br J Dermatol. 1973 Aug;89(2):133–136. doi: 10.1111/j.1365-2133.1973.tb02948.x. [DOI] [PubMed] [Google Scholar]
  21. Whittingham S., Youngchaiyud U., Mackay I. R., Buckley J. D., Morris P. J. Thyrogastric autoimmune disease. Studies on the cell-mediated immune system and histocompatibility antigens. Clin Exp Immunol. 1975 Feb;19(2):289–299. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES