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. 1976 Jan;23(1):69–72.

IgM levels and IgM-mediated immune responses in patients with acute hepatitis A, acute hepatitis B and chronic HB antigenaemia.

W H Dietz Jr, O Porcell, T E Moon, C J Peters, R H Purcell
PMCID: PMC1538362  PMID: 1261090

Abstract

Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A, acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed in both types of acute hepatitis, but not in chronic hepatitis B antigenaemia. There was no correlation of the IgM level with either the prevalence or titre of any IgM-mediated immune response studied. These data suggest that the IgM elevations in both types of hepatitis may reflect virus-specific IgM synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATWATER E. C., JACOX R. F. The latex-fixation test in patients with liver disease. Ann Intern Med. 1963 Mar;58:419–425. doi: 10.7326/0003-4819-58-3-419. [DOI] [PubMed] [Google Scholar]
  2. Altemeier W. A., 3rd, Bellanti J. A., Buescher E. L. The IgM response of children to Salmonella typhosa vaccine. I. Measurements of anti-typhoid concentrations and their proportions of total serum IgM globulins. J Immunol. 1969 Nov;103(5):917–923. [PubMed] [Google Scholar]
  3. BONOMO L., LOSPALLUTO J., ZIFF M. Anti-gamma globulin factors in liver disease. Arthritis Rheum. 1963 Apr;6:104–114. doi: 10.1002/art.1780060203. [DOI] [PubMed] [Google Scholar]
  4. Billewicz W. Z., McGregor I. A., Roberts D. F., Rowe D. S., Wilson R. J. Family studies in immunoglobulin levels. Clin Exp Immunol. 1974 Jan;16(1):13–21. [PMC free article] [PubMed] [Google Scholar]
  5. Dudley F. J., O'Shea M. J., Sherlock S. Serum autoantibodies in hepatitis associated antigen (HAA) positive patients. A possible index of cell-mediated immunity to the associated-infective agent. Clin Exp Immunol. 1973 Mar;13(3):367–372. [PMC free article] [PubMed] [Google Scholar]
  6. Farrow L. J., Holborow E. J., Johnson G. D., Lamb S. G., Stewart J. S., Taylor P. E., Zuckerman A. J. Autoantibodies and the hepatitis-associated antigen in acute infective hepatitis. Br Med J. 1970 Jun 20;2(5711):693–695. doi: 10.1136/bmj.2.5711.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Holland P. V., Purcell R. H., Smith H., Alter H. J. Subtyping of hepatitis-associated antigen (HB-Ag); simplified technique with counterelectrophoresis. J Immunol. 1972 Sep;109(3):420–425. [PubMed] [Google Scholar]
  8. Lander J. J., Alter H. J., Purcell R. H. Frequency of antibody to hepatitis-associated antigen as measured by a new radioimmunoassay technique. J Immunol. 1971 May;106(5):1166–1171. [PubMed] [Google Scholar]
  9. Lichtman M. A., Vaughan J. H., Hames C. G. The distribution of serum immunoglobulins, anti-gamma-G globulins ("rheumatoid factors") and antinuclear antibodies in White and Negro subjects in Evans County, Georgia. Arthritis Rheum. 1967 Jun;10(3):204–215. doi: 10.1002/art.1780100306. [DOI] [PubMed] [Google Scholar]
  10. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  11. Miller M. E., Mellman, Cohen M. M., Kohn G., Dietz W. H., Jr Depressed mmunoglobulin G in newborn infants witDown's syndrome. J Pediatr. 1969 Dec;75(6):996–1000. doi: 10.1016/s0022-3476(69)80337-9. [DOI] [PubMed] [Google Scholar]
  12. PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]
  13. Peters C. J., Johnson K. M. Serum immunoglobulin levels in Australia antigen positive and Australia antigen negative hepatitis. Clin Exp Immunol. 1972 Jul;11(3):381–391. [PMC free article] [PubMed] [Google Scholar]
  14. Purcell R. H., Holland P. V., Walsh J. H., Wong D. C., Morrow A. G., Chanock R. M. A complement-fixation test for measuring Australia antigen and antibody. J Infect Dis. 1969 Sep;120(3):383–386. doi: 10.1093/infdis/120.3.383. [DOI] [PubMed] [Google Scholar]
  15. Reeves W. C., Peters C. J., Lander J. J., Purcell R. H., Johnson K. M. Differences in the prevalence of hepatitis B antigen and antibody among Panamanian Indian populations. J Infect Dis. 1973 Sep;128(3):265–270. doi: 10.1093/infdis/128.3.265. [DOI] [PubMed] [Google Scholar]
  16. Vischer T. L. Australia antigen and autoantibodies in chronic hepatitis. Br Med J. 1970 Jun 20;2(5711):695–698. doi: 10.1136/bmj.2.5711.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wright R. Australia antigen and smooth-muscle antibody in acute and chronic hepatitis. Lancet. 1970 Mar 7;1(7645):521–522. doi: 10.1016/S0140-6736(70)91605-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ziegenfuss J. F., Jr, Miller J., Rossman D. Rheumatoid factor and Australia antigen. N Engl J Med. 1971 May 13;284(19):1104–1104. doi: 10.1056/NEJM197105132841919. [DOI] [PubMed] [Google Scholar]

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