Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1976 Mar;23(3):562–567.

The effect of amino acid restricted diets on the clearance of 125I-labelled polyvinyl pyrrolidone in mice.

H M Coovadia, J F Soothill
PMCID: PMC1538386  PMID: 947648

Abstract

Impaired overall phagocytic function, as measured by clearance of radio-labelled polyvinyl pyrrolidone from the blood (KPVP), has been demonstrated in mice whose dietary intake of the essential amino acids phenylalanine and tryptophan was reduced to less than a quarter of that in a standard diet which supported optimal growth. This was associated with loss in weight of body, liver, spleen and thymus and an increase in the phagocytic index, alphaPVP.

Full text

PDF
562

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooper W. C., Good R. A., Mariani T. Effects of protein insufficiency on immune responsiveness. Am J Clin Nutr. 1974 Jun;27(6):647–664. doi: 10.1093/ajcn/27.6.647. [DOI] [PubMed] [Google Scholar]
  2. Ersser R. S. Ion-exchange chromatography of the more basic amino acids of protein hydrolysates using stepwise changes of buffers containing borate ions. J Chromatogr. 1975 Dec 24;115(2):612–615. doi: 10.1016/s0021-9673(01)98968-x. [DOI] [PubMed] [Google Scholar]
  3. GORDON A. S., KATSH G. F. The adrenal cortex and the response of the fixed macrophagic cell to chronic inanition. Anat Rec. 1952 Feb;112(2):153–175. doi: 10.1002/ar.1091120203. [DOI] [PubMed] [Google Scholar]
  4. Hanley W. B., Linsao L., Davidson W., Moes C. A. Malnutrition with early treatment of phenylketonuria. Pediatr Res. 1970 Jul;4(4):318–327. doi: 10.1203/00006450-197007000-00002. [DOI] [PubMed] [Google Scholar]
  5. Jose D. G., Good R. A. Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice. J Exp Med. 1973 Jan 1;137(1):1–9. doi: 10.1084/jem.137.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Morgan A. G., Soothill J. F. Relationship between macrophage clearance of PVP and affinity of anti-protein antibody response in inbred mouse strains. Nature. 1975 Apr 24;254(5502):711–712. doi: 10.1038/254711a0. [DOI] [PubMed] [Google Scholar]
  8. Passwell J. H., Steward M. W., Soothill J. F. The effects of protein malnutrition on macrophage function and the amount and affinity of antibody response. Clin Exp Immunol. 1974 Jul;17(3):491–495. [PMC free article] [PubMed] [Google Scholar]
  9. Rouse B. M. Phenylalanine deficiency syndrome. J Pediatr. 1966 Aug;69(2):246–249. doi: 10.1016/s0022-3476(66)80327-x. [DOI] [PubMed] [Google Scholar]
  10. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  11. Theuer R. C. Effect of essential amino acid restriction on the growth of female C57BL mice and their implanted BW10232 adenocarcinomas. J Nutr. 1971 Feb;101(2):223–232. doi: 10.1093/jn/101.2.223. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES