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. 1976 Mar;23(3):578–581.

Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells.

D W Palmer, M J Dauphinée, E Murphy, N Talal
PMCID: PMC1538388  PMID: 133009

Abstract

The one-way mixed lymphocyte reaction was employed to study proliferative responses to antigens by mature, immunocompetent T cells from NZB mice 3 weeks to 4 months old. Compared to cells from control mice of the same H-2 type, thymus, spleen and lymph node cells from NZB mice were hyperactive in this response. The results are discussed in relation to possible effects of chronic stimulation by endogenous type C leukaemia virus upon differentiation of functional T cells or upon regulation by T cells of other T-cell functions, including augmentation of antibody responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allan D., Crampton F. I., Jenkins P. The effect of Freund's complete adjuvant on the cellular response in mice to sheep erythrocytes. Clin Exp Immunol. 1975 Jan;19(1):149–158. [PMC free article] [PubMed] [Google Scholar]
  2. Allison A. C., Davies A. J. Requirement of thymus-dependent lymphocytes for potentiation by adjuvants of antibody formation. Nature. 1971 Oct 1;233(5318):330–332. doi: 10.1038/233330a0. [DOI] [PubMed] [Google Scholar]
  3. Dauphinée M. J., Palmer D. W., Talal N. Evidence for an abnormal microenvironment in the thymus of New Zealand black mice. J Immunol. 1975 Oct;115(4):1054–1059. [PubMed] [Google Scholar]
  4. Gazdar A. F., Beitzel W., Talal N. The age related responses of New Zealand mice to a murine sarcoma virus. Clin Exp Immunol. 1971 Mar;8(3):501–509. [PMC free article] [PubMed] [Google Scholar]
  5. Gelfand M. C., Steinberg A. D. Mechanism of allograft rejection in New Zealand mice. I. Cell synergy and its age-dependent loss. J Immunol. 1973 Jun;110(6):1652–1662. [PubMed] [Google Scholar]
  6. Hartzman R. J., Bach M. L., Bach F. H., Thurman G. B., Sell K. W. Precipitation of radioactively labeled samples: a semi-automatic multiple-sample processor. Cell Immunol. 1972 Jun;4(2):182–186. doi: 10.1016/0008-8749(72)90018-4. [DOI] [PubMed] [Google Scholar]
  7. Jacobs M. E., Steinberg A. D., Gordon J. K., Talal N. Adjuvant effects on poly I poly C in New Zealand mice. Arthritis Rheum. 1972 Mar-Apr;15(2):201–207. doi: 10.1002/art.1780150211. [DOI] [PubMed] [Google Scholar]
  8. Konda S., Nakao Y., Smith R. T. Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation. J Exp Med. 1972 Dec 1;136(6):1461–1477. doi: 10.1084/jem.136.6.1461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Konda S., Nakao Y., Smith R. T. The stimulatory effect of tumor bearing upon the T- and B-cell subpopulations of the mouse spleen. Cancer Res. 1973 Oct;33(10):2247–2256. [PubMed] [Google Scholar]
  10. Leventhal B. G., Talal N. Response of NZB and NZB-NZW spleen cells to mitogenic agents. J Immunol. 1970 Apr;104(4):918–923. [PubMed] [Google Scholar]
  11. Levy J. A. Autoimmunity and neoplasia. The possible role of C-type viruses. Am J Clin Pathol. 1974 Aug;62(2):258–280. doi: 10.1093/ajcp/62.2.258. [DOI] [PubMed] [Google Scholar]
  12. Mosier D. E., Pierce C. W. Functional maturation of thymic lymphocyte populations in vitro. J Exp Med. 1972 Dec 1;136(6):1484–1500. doi: 10.1084/jem.136.6.1484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nelson D. S. Immunity to infection, allograft immunity and tumour immunity: parallels and contrasts. Transplant Rev. 1974;19(0):226–254. doi: 10.1111/j.1600-065x.1974.tb00134.x. [DOI] [PubMed] [Google Scholar]
  14. Oldstone M. B., Dixon F. J. Immune complex disease in chronic viral infections. J Exp Med. 1971 Sep 1;134(3 Pt 2):32s–40s. [PubMed] [Google Scholar]
  15. Playfair J. H., Marshall-Clarke S. Cross-reactions between erythrocytes at the T-cell level. Immunology. 1973 Mar;24(3):579–588. [PMC free article] [PubMed] [Google Scholar]
  16. Playfair J. H., Marshall-Clarke S. Induction of red cell autoantibodies in normal mice. Nat New Biol. 1973 Jun 13;243(128):213–214. doi: 10.1038/newbio243213a0. [DOI] [PubMed] [Google Scholar]
  17. Playfair J. H. Strain differences in the immune response of mice. I. The neonatal response to sheep red cells. Immunology. 1968 Jul;15(1):35–50. [PMC free article] [PubMed] [Google Scholar]
  18. Rich S. S., Rich R. R. Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes. J Exp Med. 1974 Dec 1;140(6):1588–1603. doi: 10.1084/jem.140.6.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Schimpl A., Wecker E. Stimulation of IgG antibody response in vitro by T cell-replacing factor. J Exp Med. 1973 Feb 1;137(2):547–552. doi: 10.1084/jem.137.2.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stobo J. D., Talal N., Paul W. E. Lymphocyte classes in New Zealand mice. I. Ontogeny and mitogen responsiveness of thymocytes and thymus-derived lymphocytes. J Immunol. 1972 Oct;109(4):692–700. [PubMed] [Google Scholar]
  21. Stobo J. D., Talal N., Paul W. E. Lymphocyte classes in New Zealand mice. II. Decreased frequency of immunoglobulin-bearing lymphocytes and increased frequency of lymphocytes lacking detectable theta or immunoglobulin determinants. J Immunol. 1972 Oct;109(4):701–710. [PubMed] [Google Scholar]
  22. Stutman O. Lymphocyte subpopulations in NZB mice: deficit of thymus-dependent lymphocytes. J Immunol. 1972 Sep;109(3):602–611. [PubMed] [Google Scholar]
  23. Stutman O., Yunis E. J., Good R. A. Deficient immunologic functions of NZB mice. Proc Soc Exp Biol Med. 1968 Apr;127(4):1204–1207. doi: 10.3181/00379727-127-32910. [DOI] [PubMed] [Google Scholar]
  24. Zatz M. M., Mellors R. C., Lance E. M. Changes in lymphoid populations of ageing CBA and NZB mice. Clin Exp Immunol. 1971 Mar;8(3):491–500. [PMC free article] [PubMed] [Google Scholar]

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