Abstract
Direct evidence for the existence of Fc receptors on the surface of first trimester and term human placental cells has been obtained by the use of an antibody-coated red cell (EA) rosette assay. The modification of a Ficoll density gradient separation procedure for placental cell population in conjunction with dye uptake experiments, cytocentrifuge preparations and cytological analysis has enabled an identification of the rosette-forming cells in the mature placenta as predominantly, if not entirely, syncytiotrophoblastic. The significance of these findings, together with those demonstrating the presence of cell-surface Fc receptors on the chorionic membrane, are considered in relation to the transmission of immunoglobulin from mother to foetus and to the protection of the foetus as an intra-uterine allograft.
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- Berken A., Benacerraf B. Properties of antibodies cytophilic for macrophages. J Exp Med. 1966 Jan 1;123(1):119–144. doi: 10.1084/jem.123.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brambell F. W. The transmission of immunity from mother to young and the catabolism of immunoglobulins. Lancet. 1966 Nov 19;2(7473):1087–1093. doi: 10.1016/s0140-6736(66)92190-8. [DOI] [PubMed] [Google Scholar]
- Hemmings W. A., Williams E. W. The attachment of IgG to cell components: a reconsideration of Brambell's receptor hypothesis of protein transmission. Proc R Soc Lond B Biol Sci. 1974 Sep 17;187(1087):209–219. doi: 10.1098/rspb.1974.0070. [DOI] [PubMed] [Google Scholar]
- MORRIS I. G. THE TRANSMISSION OF ANTIBODIES AND NORMAL GAMMA-GLOBULINS ACROSS THE YOUNG MOUSE GUT. Proc R Soc Lond B Biol Sci. 1964 May 19;160:276–292. doi: 10.1098/rspb.1964.0040. [DOI] [PubMed] [Google Scholar]
- Ptak W., Pryjma J., Moskalewski S. Macrophages in mouse placenta: immunogenicity of macrophage-associated antigen. J Reticuloendothel Soc. 1974 Jul;16(1):15–20. [PubMed] [Google Scholar]
- Sonada S., Schlamowitz M. Specificity of the in vitro binding of IgG and rabbit serum albumin (RSA) to rabbit yolk sac membrane. J Immunol. 1972 May;108(5):1345–1352. [PubMed] [Google Scholar]
- Wild A. E. Protein transport across the placenta. Symp Soc Exp Biol. 1974;(28):521–546. [PubMed] [Google Scholar]
- Zembala M., Asherson G. L. The rapid purification of peritoneal exudate macrophages by ficoll (polysucrose) density gradient centrifugation. Immunology. 1970 Oct;19(4):677–681. [PMC free article] [PubMed] [Google Scholar]