Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1976 May;24(2):323–327.

Antibody-dependent direct cytotoxicity of human lymphocytes. II. Studies on peripheral blood lymphocytes, synovial fluid cells and sera from patients with rheumatoid arthritis.

M A Scheinberg, E S Cathcart
PMCID: PMC1538418  PMID: 1084244

Abstract

Antibody-dependent direct cytotoxicity (ADDC) by human lymphocytes was evaluated in patients with rheumatoid arthritis and normal controls. Purified peripheral blood and synovial fluid lymphocytes mediated normal ADDC when compared to control subjects. No correlation could be obtained between the percentages of T, B and null cells in effector cell populations and the degree of 51Cr released from target cells. Sera from 50% of patients with rheumatoid arthritis inhibited ADDC by normal lymphocytes; the degree of inhibition did not correlate with the titre of IgM rheumatoid factor. The pathogenic implications of these findings are discussed.

Full text

PDF
323

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnett I. G., MacLennan I. C. Inhibitory effect of rheumatoid sera on cell damage by lymphocytes. Ann Rheum Dis. 1972 Sep;31(5):425–425. doi: 10.1136/ard.31.5.425-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brenner A. I., Scheinberg M. A., Cathcart E. S. Surface characteristics of synovial fluid and peripheral blood lymphocytes in inflammatory arthritis. Arthritis Rheum. 1975 Jul-Aug;18(4):297–303. doi: 10.1002/art.1780180402. [DOI] [PubMed] [Google Scholar]
  3. Calder E. A., Penhale W. J., McLeman D., Barnes E. W., Irvine W. J. Lymphocyte-dependent antibody-mediated cytotoxicity in Hashimoto thyroiditis. Clin Exp Immunol. 1973 Jun;14(2):153–158. [PMC free article] [PubMed] [Google Scholar]
  4. Campbell A. C., Maclennan I. C., Snaith M. L., Barnett I. G. Selective deficiency of cytotoxic B lymphocytes in man. Clin Exp Immunol. 1972 Sep;12(1):1–8. [PMC free article] [PubMed] [Google Scholar]
  5. GOOD R. A., ROTSTEIN J., MAZZITELLO W. F. The simultaneous occurrence of rheumatoid arthritis and agammaglobulinemia. J Lab Clin Med. 1957 Mar;49(3):343–357. [PubMed] [Google Scholar]
  6. Gipson T. G., Daniels C. A. The effect of rheumatoid factor on the immune lysis of vaccinia virus-infected cells. Clin Immunol Immunopathol. 1975 May;4(1):16–23. doi: 10.1016/0090-1229(75)90034-3. [DOI] [PubMed] [Google Scholar]
  7. Hallberg T. In vitro cytotoxicity of human lymphocytes for sensitized chicken erythrocytes is inhibited by sera from rheumatoid arthritis patients. Scand J Immunol. 1972;1(4):329–338. doi: 10.1111/j.1365-3083.1972.tb03298.x. [DOI] [PubMed] [Google Scholar]
  8. Hallberg T. Inhibition of cytotoxicity of nonimmune human lymphocytes for sensitized chicken erythrocytes by aggregated human IgG. Scand J Immunol. 1974;3(1):117–125. doi: 10.1111/j.1365-3083.1974.tb01239.x. [DOI] [PubMed] [Google Scholar]
  9. MOELLER E. CONTACT-INDUCED CYTOTOXICITY BY LYMPHOID CELLS CONTAINING FOREIGN ISOANTIGENS. Science. 1965 Feb 19;147(3660):873–879. doi: 10.1126/science.147.3660.873. [DOI] [PubMed] [Google Scholar]
  10. O'Toole C., Stejskal V., Perlmann P., Karlsson M. Lymphoid cells mediating tumor-specific cytotoxicity to carcinoma of the urinary bladder. Separation of the effector population using a surface marker. J Exp Med. 1974 Mar 1;139(3):457–466. doi: 10.1084/jem.139.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Perlmann P., Perlmann H. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes. Cell Immunol. 1970 Sep;1(3):300–315. doi: 10.1016/0008-8749(70)90051-1. [DOI] [PubMed] [Google Scholar]
  12. Perlmann P., Perlmann H., Larsson A., Wåhlin B. Antibody dependent cytolytic effector lymphocytes (K cells) in human blood. J Reticuloendothel Soc. 1975 Apr;17(4):241–250. [PubMed] [Google Scholar]
  13. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  14. Rachelefsky G. S., McConnachie P. R., Ammann A. J., Terasaki P. I., Stiehm E. R. Antibody-dependent lymphocyte killer function in human immunodeficiency diseases. Clin Exp Immunol. 1975 Jan;19(1):1–9. [PMC free article] [PubMed] [Google Scholar]
  15. Scheinberg M. A., Cathcart E. S. Antibody-dependent direct cytotoxicity of human lymphocytes. I. Studies on peripheral blood lymphocytes and sera of patients with systemic lupus erythematosus. Clin Exp Immunol. 1976 May;24(2):317–322. [PMC free article] [PubMed] [Google Scholar]
  16. Scheinberg M. A., Cathcart E. S. B cell and T cell lymphopenia in systemic lupus erythematosus. Cell Immunol. 1974 May;12(2):309–314. doi: 10.1016/0008-8749(74)90083-5. [DOI] [PubMed] [Google Scholar]
  17. Smith C. A. Properties of synovial cells in culture. J Exp Med. 1971 Sep 1;134(3 Pt 2):306s–312s. [PubMed] [Google Scholar]
  18. Van Boxel J. A., Stobo J. D., Paul W. E., Green I. Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science. 1972 Jan 14;175(4018):194–196. doi: 10.1126/science.175.4018.194. [DOI] [PubMed] [Google Scholar]
  19. Winchester R. J., Kunkel H. G., Agnello V. Occurrence of -globulin complexes in serum and joint fluid of rheumatoid arthritis patients: use of monoclonal rheumatoid factors as reagents for their demonstration. J Exp Med. 1971 Sep 1;134(3 Pt 2):286s–295s. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES