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. 1976 Feb;23(2):347–354.

Generation of T-cell function in organ culture of foetal mouse thymus. I. Mitogen responsiveness

J H Robinson, J J T Owen
PMCID: PMC1538482

Abstract

An in vitro model for the study of T-cell ontogeny is presented. The generation of mitogen responsive thymocytes in embryonic mouse thymus using an organ culture system is described. The pattern of development of mitogen responsiveness in vitro is similar to that seen in vivo except that responses were greater and appeared later in culture than in thymus of a temporally equivalent age in vivo. This suggests that organ culture selectively enriches T-cell activity and thus offers a novel approach to the analysis of T-cell reactivity as well as to the understanding of defects in T-cell development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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