Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1976 Apr;24(1):139–145.

The reactivity of spleen cells from malarious rats to non-specific mitogens.

D T Spira, J Golenser, I Gery
PMCID: PMC1538488  PMID: 780016

Abstract

The reaction of spleen cells from rats infected with Plasmodium berghei to non-specific mitogens has been measured. The cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-A and by bacterial lypopolysaccharide. In addition the release of lymphocyte activating factor (LAF) by splenic macrophages has been assayed using a heterologous thymocyte culture. The reactivity of spleen lymphocytes from malarious rats is severly affected. The cells do not react either to the T cell-specific mitogens or to the B-cell stimulant. The reactivity of macrophages, as measured by the release of LAF, was not altered by the disease.

Full text

PDF
139

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bash J. A., Waksman B. H. The suppressive effect of immunization on the proliferative responses of rat T cells in vitro. J Immunol. 1975 Feb;114(2 Pt 2):782–787. [PubMed] [Google Scholar]
  2. Chavin S. I. Studies on the antigenic constituents of Plasmodium berghei. I. Immunologic analysis of the parasite constituents. II. Fractionation of the parasite constituents. Mil Med. 1966 Sep;131(9 Suppl):1124–1136. [PubMed] [Google Scholar]
  3. Gershon R. K., Gery I., Waksman B. H. Suppressive effects of in vivo immunization on PHA responses in vitro. J Immunol. 1974 Jan;112(1):215–221. [PubMed] [Google Scholar]
  4. Gery I., Gershon R. K., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. J Exp Med. 1972 Jul 1;136(1):128–142. doi: 10.1084/jem.136.1.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gery I., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). J Exp Med. 1972 Jul 1;136(1):143–155. doi: 10.1084/jem.136.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Golenser J., Spira D. T., Zuckerman A. Dynamics of thymidine incorporation by spleen cells from rats infected with Plasmodium berghei. Clin Exp Immunol. 1975 Nov;22(2):364–371. [PMC free article] [PubMed] [Google Scholar]
  7. Greaves M., Janossy G. Elicitation of selective T and B lymphocyte responses by cell surface binding ligands. Transplant Rev. 1972;11:87–130. doi: 10.1111/j.1600-065x.1972.tb00047.x. [DOI] [PubMed] [Google Scholar]
  8. KRETSCHMAR W., JERUSALEM C. MILZ UND MALARIA. DER INFEKTIONSVERLAUF (PLASMODIUM BERGHEI) IN SPLENEKTOMIERTEN NMRI-MAEUSEN UND SEINE DEUTUNG ANHAND DER HISTOPATHOLOGISCHEN VERAENDERUNGEN DER MILZ NICHTSPLENEKTOMIERTER MAEUSE. Z Tropenmed Parasitol. 1963 Oct;14:279–310. [PubMed] [Google Scholar]
  9. Krettli A. U., Nussenzweig R. Depletion of T and B lymphocytes during malarial infections. Cell Immunol. 1974 Sep;13(3):440–446. doi: 10.1016/0008-8749(74)90263-9. [DOI] [PubMed] [Google Scholar]
  10. Maegraith B., Fletcher A. The pathogenesis of mammalian malaria. Adv Parasitol. 1972;10:49–75. doi: 10.1016/s0065-308x(08)60172-4. [DOI] [PubMed] [Google Scholar]
  11. McGregor I. A., Turner M. W., Williams K., Hall P. Soluble antigens in the blood of African patients with severe plasmodium falciparum malaria. Lancet. 1968 Apr 27;1(7548):881–884. doi: 10.1016/s0140-6736(68)90237-7. [DOI] [PubMed] [Google Scholar]
  12. RAY A. P., SHARMA G. K. Experimental studies on liver injury in malaria. II. Pathogenesis. Indian J Med Res. 1958 May;46(3):367–376. [PubMed] [Google Scholar]
  13. SINGER I. The cellular reactions to infections with Plasmodium berghei in the white mouse. J Infect Dis. 1954 May-Jun;94(3):241–261. doi: 10.1093/infdis/94.3.241. [DOI] [PubMed] [Google Scholar]
  14. Scott M. T. Biological effects of the adjuvant Corynebacterium parvum. I. Inhibition of PHA, mixed lymphocyte and GVH reactivity. Cell Immunol. 1972 Nov;5(3):459–468. doi: 10.1016/0008-8749(72)90072-x. [DOI] [PubMed] [Google Scholar]
  15. Scott M. T. Biological effects of the adjuvant Corynebacterium parvum. II. Evidence for macrophage-T-cell interaction. Cell Immunol. 1972 Nov;5(3):469–479. doi: 10.1016/0008-8749(72)90073-1. [DOI] [PubMed] [Google Scholar]
  16. Ward P. A. Conran PB: Immunopathologic studies of simian malaria. Mil Med. 1966 Sep;131(9 Suppl):1225–1232. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES