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. 1998 Sep;39(9):559–565.

Salmonella typhimurium DT104: a virulent and drug-resistant pathogen.

C Poppe 1, N Smart 1, R Khakhria 1, W Johnson 1, J Spika 1, J Prescott 1
PMCID: PMC1539434  PMID: 9752592

Abstract

Salmonella typhimurium phage type (PT) or definitive type (DT) 104 is a virulent pathogen for humans and animals, particularly cattle. It has been isolated increasingly from humans and animals in the United Kingdom and several other European countries and, more recently, in the United States and Canada. Humans may acquire the infection from foods of animal origin contaminated with the infective organism. Farm families are particularly at risk of acquiring the infection by contact with infected animals or by drinking unpasteurized milk. The symptoms in cattle are watery to bloody diarrhea, a drop in milk production, pyrexia, anorexia, dehydration and depression. Infection may result in septicemic salmonellosis and, upon necropsy, a fibrinonecrotic enterocolitis may be observed. The infection occurs more commonly in the calving season than at other times. Feedlot cattle and pigs may also be affected. Prolonged carriage and shedding of the pathogen may occur. Symptoms in humans consist of diarrhea, fever, headache, nausea, abdominal pain, vomiting, and, less frequently, blood in the stool. Salmonella typhimurium DT104 strains are commonly resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline.

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Selected References

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  1. Besser T. E., Gay C. C., Gay J. M., Hancock D. D., Rice D., Pritchett L. C., Erickson E. D. Salmonellosis associated with S typhimurium DT104 in the USA. Vet Rec. 1997 Jan 18;140(3):75–75. [PubMed] [Google Scholar]
  2. Bezanson G. S., Khakhria R., Duck D., Lior H. Molecular analysis confirms food source and simultaneous involvement of two distinct but related subgroups of Salmonella typhimurium bacteriophage type 10 in major interprovincial Salmonella outbreak. Appl Environ Microbiol. 1985 Nov;50(5):1279–1284. doi: 10.1128/aem.50.5.1279-1284.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brisabois A., Cazin I., Breuil J., Collatz E. Surveillance of antibiotic resistance in Salmonella. Euro Surveill. 1997 Mar;2(3):19–20. doi: 10.2807/esm.02.03.00181-en. [DOI] [PubMed] [Google Scholar]
  4. Davies A., O'Neill P., Towers L., Cooke M. An outbreak of Salmonella typhimurium DT104 food poisoning associated with eating beef. Commun Dis Rep CDR Rev. 1996 Oct 11;6(11):R159–R162. [PubMed] [Google Scholar]
  5. Evans S., Davies R. Case control study of multiple-resistant Salmonella typhimurium DT104 infection of cattle in Great Britain. Vet Rec. 1996 Dec 7;139(23):557–558. [PubMed] [Google Scholar]
  6. Fone D. L., Barker R. M. Associations between human and farm animal infections with Salmonella typhimurium DT104 in Herefordshire. Commun Dis Rep CDR Rev. 1994 Oct 14;4(11):R136–R140. [PubMed] [Google Scholar]
  7. Frost J. A., Ward L. R., Rowe B. Acquisition of a drug resistance plasmid converts Salmonella enteritidis phage type 4 to phage type 24. Epidemiol Infect. 1989 Oct;103(2):243–248. doi: 10.1017/s0950268800030594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Glynn M. K., Bopp C., Dewitt W., Dabney P., Mokhtar M., Angulo F. J. Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States. N Engl J Med. 1998 May 7;338(19):1333–1338. doi: 10.1056/NEJM199805073381901. [DOI] [PubMed] [Google Scholar]
  9. Griggs D. J., Hall M. C., Jin Y. F., Piddock L. J. Quinolone resistance in veterinary isolates of Salmonella. J Antimicrob Chemother. 1994 Jun;33(6):1173–1189. doi: 10.1093/jac/33.6.1173. [DOI] [PubMed] [Google Scholar]
  10. Hollingsworth J., Kaplan B. Federal agencies collaborate to control dangerous new Salmonella strain. J Am Vet Med Assoc. 1997 Jun 15;210(12):1712–1716. [PubMed] [Google Scholar]
  11. Low J. C., Angus M., Hopkins G., Munro D., Rankin S. C. Antimicrobial resistance of Salmonella enterica typhimurium DT104 isolates and investigation of strains with transferable apramycin resistance. Epidemiol Infect. 1997 Apr;118(2):97–103. doi: 10.1017/s0950268896007339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Low J. C., Hopkins G., King T., Munro D. Antibiotic resistant Salmonella typhimurium DT104 in cattle. Vet Rec. 1996 Jun 29;138(26):650–651. [PubMed] [Google Scholar]
  13. Low J. C., Tennant B., Munro D. Multiple-resistant Salmonella typhimurium DT104 in cats. Lancet. 1996 Nov 16;348(9038):1391–1391. doi: 10.1016/s0140-6736(05)65465-7. [DOI] [PubMed] [Google Scholar]
  14. Penny C. D., Low J. C., Nettleton P. F., Scott P. R., Sargison N. D., Strachan W. D., Honeyman P. C. Concurrent bovine viral diarrhoea virus and Salmonella typhimurium DT104 infection in a group of pregnant dairy heifers. Vet Rec. 1996 May 18;138(20):485–489. doi: 10.1136/vr.138.20.485. [DOI] [PubMed] [Google Scholar]
  15. Rodrigue D. C., Cameron D. N., Puhr N. D., Brenner F. W., St Louis M. E., Wachsmuth I. K., Tauxe R. V. Comparison of plasmid profiles, phage types, and antimicrobial resistance patterns of Salmonella enteritidis isolates in the United States. J Clin Microbiol. 1992 Apr;30(4):854–857. doi: 10.1128/jcm.30.4.854-857.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rowe B., Ward L. R., Threlfall E. J. Ciprofloxacin and typhoid fever. Lancet. 1992 Mar 21;339(8795):740–740. [PubMed] [Google Scholar]
  17. Ryan C. A., Nickels M. K., Hargrett-Bean N. T., Potter M. E., Endo T., Mayer L., Langkop C. W., Gibson C., McDonald R. C., Kenney R. T. Massive outbreak of antimicrobial-resistant salmonellosis traced to pasteurized milk. JAMA. 1987 Dec 11;258(22):3269–3274. [PubMed] [Google Scholar]
  18. Sandvang D., Aarestrup F. M., Jensen L. B. Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104. FEMS Microbiol Lett. 1998 Mar 1;160(1):37–41. doi: 10.1111/j.1574-6968.1998.tb12887.x. [DOI] [PubMed] [Google Scholar]
  19. Sharp M. W., Rawson B. C. Persistent Salmonella typhimurium PT 104 infection in a dairy herd. Vet Rec. 1992 Oct 17;131(16):375–376. doi: 10.1136/vr.131.16.375. [DOI] [PubMed] [Google Scholar]
  20. Smith B. P., Habasha F. G., Reina-Guierra M., Hardy A. J. Immunization of calves against salmonellosis. Am J Vet Res. 1980 Dec;41(12):1947–1951. [PubMed] [Google Scholar]
  21. Threlfall E. J., Brown D. J., Rowe B., Ward L. R. Occurrence of S typhimurium DT204c in poultry in England and Wales. Vet Rec. 1990 Sep 1;127(9):234–234. [PubMed] [Google Scholar]
  22. Threlfall E. J., Frost J. A., Ward L. R., Rowe B. Epidemic in cattle and humans of Salmonella typhimurium DT 104 with chromosomally integrated multiple drug resistance. Vet Rec. 1994 May 28;134(22):577–577. doi: 10.1136/vr.134.22.577. [DOI] [PubMed] [Google Scholar]
  23. Threlfall E. J., Frost J. A., Ward L. R., Rowe B. Increasing spectrum of resistance in multiresistant Salmonella typhimurium. Lancet. 1996 Apr 13;347(9007):1053–1054. doi: 10.1016/s0140-6736(96)90199-3. [DOI] [PubMed] [Google Scholar]
  24. Threlfall E. J., Hampton M. D., Schofield S. L., Ward L. R., Frost J. A., Rowe B. Epidemiological application of differentiating multiresistant Salmonella typhimurium DT104 by plasmid profile. Commun Dis Rep CDR Rev. 1996 Oct 11;6(11):R155–R159. [PubMed] [Google Scholar]
  25. Threlfall E.J., Ward L.R., Rowe B. Increasing incidence of resistance to trimethoprim and ciprofloxacin in epidemic Salmonella typhimurium DT104 in England and Wales. Euro Surveill. 1997 Nov;2(11):81–84. doi: 10.2807/esm.02.11.00187-en. [DOI] [PubMed] [Google Scholar]
  26. Wain J., Hoa N. T., Chinh N. T., Vinh H., Everett M. J., Diep T. S., Day N. P., Solomon T., White N. J., Piddock L. J. Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment. Clin Infect Dis. 1997 Dec;25(6):1404–1410. doi: 10.1086/516128. [DOI] [PubMed] [Google Scholar]
  27. Wall P. G., Davis S., Threlfall E. J., Ward L. R., Ewbank A. J. Chronic carriage of multidrug resistant Salmonella typhimurium in a cat. J Small Anim Pract. 1995 Jun;36(6):279–281. doi: 10.1111/j.1748-5827.1995.tb02919.x. [DOI] [PubMed] [Google Scholar]
  28. Wall P. G., Morgan D., Lamden K., Griffin M., Threlfall E. J., Ward L. R., Rowe B. Transmission of multi-resistant strains of Salmonella typhimurium from cattle to man. Vet Rec. 1995 Jun 10;136(23):591–592. doi: 10.1136/vr.136.23.591. [DOI] [PubMed] [Google Scholar]
  29. Wall P. G., Morgan D., Lamden K., Ryan M., Griffin M., Threlfall E. J., Ward L. R., Rowe B. A case control study of infection with an epidemic strain of multiresistant Salmonella typhimurium DT104 in England and Wales. Commun Dis Rep CDR Rev. 1994 Oct 14;4(11):R130–R135. [PubMed] [Google Scholar]
  30. Wall P. G., Threllfall E. J., Ward L. R., Rowe B. Multiresistant Salmonella typhimurium DT104 in cats: a public health risk. Lancet. 1996 Aug 17;348(9025):471–471. doi: 10.1016/S0140-6736(96)24033-4. [DOI] [PubMed] [Google Scholar]
  31. West A. M., Martin S. W., McEwen S. A., Clarke R. C., Tamblyn S. E. Factors associated with the presence of Salmonella spp. in dairy farm families in southwestern Ontario. Can J Public Health. 1988 Mar-Apr;79(2):119–123. [PubMed] [Google Scholar]
  32. Wray C., McLaren I., Wise R., Piddock L. J. Nalidixic acid-resistant salmonellae. Vet Rec. 1990 May 12;126(19):489–489. [PubMed] [Google Scholar]

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