Abstract
An adult mink from a farm experiencing 100% mortality in affected animals was submitted for diagnostic examination. Clinical history included signs of respiratory disease, oculonasal discharge, and thickening of footpads. Canine distemper virus and Pneumocystis carinii were identified in lung tissue, suggesting immunosuppresion and secondary infection due to morbillivirus disease.
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- Diters R. W., Nielsen S. W. Toxoplasmosis, distemper, and herpesvirus infection in a skunk (Mephitis mephitis). J Wildl Dis. 1978 Jan;14(1):132–136. doi: 10.7589/0090-3558-14.1.132. [DOI] [PubMed] [Google Scholar]
- Grosjean I., Caux C., Bella C., Berger I., Wild F., Banchereau J., Kaiserlian D. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells. J Exp Med. 1997 Sep 15;186(6):801–812. doi: 10.1084/jem.186.6.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanano R., Reifenberg K., Kaufmann S. H. Activated pulmonary macrophages are insufficient for resistance against Pneumocystis carinii. Infect Immun. 1998 Jan;66(1):305–314. doi: 10.1128/iai.66.1.305-314.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Itatani C. A. Ultrastructural morphology of intermediate forms and forms suggestive of conjugation in the life cycle of Pneumocystis carinii. J Parasitol. 1996 Feb;82(1):163–171. [PubMed] [Google Scholar]
- Kauffman C. A., Bergman A. G., O'Connor R. P. Distemper virus infection in ferrets: an animal model of measles-induced immunosuppression. Clin Exp Immunol. 1982 Mar;47(3):617–625. [PMC free article] [PubMed] [Google Scholar]
- Krakowka S., Ringler S. S., Lewis M., Olsen R. G., Axthelm M. K. Immunosuppression by canine distemper virus: modulation of in vitro immunoglobulin synthesis, interleukin release and prostaglandin E2 production. Vet Immunol Immunopathol. 1987 Jun;15(3):181–201. doi: 10.1016/0165-2427(87)90082-1. [DOI] [PubMed] [Google Scholar]
- Limper A. H., Hoyte J. S., Standing J. E. The role of alveolar macrophages in Pneumocystis carinii degradation and clearance from the lung. J Clin Invest. 1997 May 1;99(9):2110–2117. doi: 10.1172/JCI119384. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poonacha K. B., Smith H. L. Naturally occurring Tyzzer's disease as a complication of distemper and mycotic pneumonia in a dog. J Am Vet Med Assoc. 1976 Aug 15;169(4):419–420. [PubMed] [Google Scholar]
- Stephensen C. B., Welter J., Thaker S. R., Taylor J., Tartaglia J., Paoletti E. Canine distemper virus (CDV) infection of ferrets as a model for testing Morbillivirus vaccine strategies: NYVAC- and ALVAC-based CDV recombinants protect against symptomatic infection. J Virol. 1997 Feb;71(2):1506–1513. doi: 10.1128/jvi.71.2.1506-1513.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stringer J. R. Pneumocystis carinii: what is it, exactly? Clin Microbiol Rev. 1996 Oct;9(4):489–498. doi: 10.1128/cmr.9.4.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Warschkau H., Yu H., Kiderlen A. F. Activation and suppression of natural cellular immune functions by Pneumocystis carinii. Immunobiology. 1998 Feb;198(4):343–360. doi: 10.1016/S0171-2985(98)80044-2. [DOI] [PubMed] [Google Scholar]
- Wojcinski Z. W., Barker I. K. Tyzzer's disease as a complication of canine distemper in a raccoon. J Wildl Dis. 1986 Jan;22(1):55–59. doi: 10.7589/0090-3558-22.1.55. [DOI] [PubMed] [Google Scholar]