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. 1977 May;28(2):268–275.

Immunological studies of patients with asbestosis. II, Studies of circulating lymphoid cell numbers and humoral immunity.

E Kagan, A Solomon, J C Cochrane, P Kuba, P H Rocks, I Webster
PMCID: PMC1540752  PMID: 301449

Abstract

As part of an overall assessment of immunological function, several aspects of humorial immunity and circulating lymphocyte subpopulations were evaluated in a group of twenty-six patients with radiographic evidence of parenchylmal asbestosis. Statistical comparisons were made between the patient group and a comparable group of forty-five controls. Both the percentages and absolute numbers of circulating T lymphocytes were significantly reduced in the patient group compared with controls. Significant elevations of salivary secretory IgA and of serum IgA, IgG, IgM and IgE were noted amongst the patients compared with the controls. Non-organ-specific autoantibodies and cold-reactive lymphocytotoxins were present in high frequency in the patients' sera. Neoplasms were detected in four of the patients. The possible significance of these findings is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Denman A. M., Barnes R. D. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet. 1971 Jul 17;2(7716):135–140. doi: 10.1016/s0140-6736(71)92306-3. [DOI] [PubMed] [Google Scholar]
  2. Gershwin M. E., Steinberg A. D. Loss of suppressor function as a cause of lymphoid malignancy. Lancet. 1973 Nov 24;2(7839):1174–1176. doi: 10.1016/s0140-6736(73)92940-1. [DOI] [PubMed] [Google Scholar]
  3. Gleichmann E., Gleichmann H., Schwartz R. S. Immunologic induction of malignant lymphoma: genetic factors in the graft-versus-host model. J Natl Cancer Inst. 1972 Sep;49(3):793–804. [PubMed] [Google Scholar]
  4. Goldberg L. S., Cunningham J. E., Terasaki P. I. Lymphocytotoxins and pernicious anemia. Blood. 1972 Jun;39(6):862–865. [PubMed] [Google Scholar]
  5. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kagan E., Solomon A., Cochrane J. C., Beissner E. I., Gluckman J., Rocks P. H., Webster I. Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. Clin Exp Immunol. 1977 May;28(2):261–267. [PMC free article] [PubMed] [Google Scholar]
  7. Kagan E., Soskolne C. L., Zwi S., Hurwitz S., Maier G. M., Ipp T., Rabson A. R. Immunologic studies in patients with recurrent bronchopulmonary infections. Am Rev Respir Dis. 1975 Apr;111(4):441–451. doi: 10.1164/arrd.1975.111.4.441. [DOI] [PubMed] [Google Scholar]
  8. Kang K., Sera Y., Okochi T., Yamamura Y. Letter: T lymphocytes in abestosis. N Engl J Med. 1974 Oct 3;291(14):735–736. doi: 10.1056/NEJM197410032911414. [DOI] [PubMed] [Google Scholar]
  9. Lange A., Smolik R., Zatoński W., Szymańska J. Autoantibodies and serum immunoglobulin levels in asbestos workers. Int Arch Arbeitsmed. 1974 Jan 31;32(4):313–325. doi: 10.1007/BF02178970. [DOI] [PubMed] [Google Scholar]
  10. Mayer S., Falkenrodt A., Tongio M. M. Cold lymphocytotoxins in infections and parasitic infestations. Tissue Antigens. 1973;3(6):431–438. doi: 10.1111/j.1399-0039.1973.tb00513.x. [DOI] [PubMed] [Google Scholar]
  11. Miller K., Kagan E. The in vivo effects of asbestos on macrophage membrane structure and population characteristics of macrophages: a scanning electron microscope study. J Reticuloendothel Soc. 1976 Aug;20(2):159–170. [PubMed] [Google Scholar]
  12. Naito S., Mickey M. R., Hirata A., Terasaki P. I. Autolymphocytotoxins following immunization by pregnancy, transplantation, and disease. Tissue Antigens. 1971;1(5):219–228. doi: 10.1111/j.1399-0039.1971.tb00099.x. [DOI] [PubMed] [Google Scholar]
  13. Parkes W. R. Asbestos-related disorders. Br J Dis Chest. 1973 Oct;67(4):261–300. doi: 10.1016/s0007-0971(73)80001-4. [DOI] [PubMed] [Google Scholar]
  14. Schwartz R. S. Another look at immunologic surveillance. N Engl J Med. 1975 Jul 24;293(4):181–184. doi: 10.1056/NEJM197507242930406. [DOI] [PubMed] [Google Scholar]
  15. Steffen C., Thumb N., Frank O., Eberl R., Tausch G., Boros M. Demonstration of lymphocytotoxins in rheumatoid arthritis in comparison with clinical course and other antibody activities. Z Immunitatsforsch Exp Klin Immunol. 1973 Jun;145(4):303–311. [PubMed] [Google Scholar]
  16. Strickland R. G., Friedler E. M., Henderson C. A., Wilson I. D., Williams R. D., Jr Serum lymphocytotoxins in inflammatory bowel disease. Studies of frequency and specificity for lymphocyte subpopulations. Clin Exp Immunol. 1975 Sep;21(3):384–393. [PMC free article] [PubMed] [Google Scholar]
  17. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  18. Turner-Warwick M. Immunology and asbestosis. Proc R Soc Med. 1973 Sep;66(9):927–930. [PMC free article] [PubMed] [Google Scholar]
  19. Turner-Warwick M., Parkes W. R. Circulating rheumatoid and antinuclear factors in asbestos workers. Br Med J. 1970 Aug 29;3(5721):492–495. doi: 10.1136/bmj.3.5721.492. [DOI] [PMC free article] [PubMed] [Google Scholar]

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