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. 1977 May;28(2):233–240.

The relationship of defective cell-mediated immunity to visceral disease in systemic sclerosis.

P Hughes, S Holt, N R Rowell, I D Allonby, K Janis, J K Dodd
PMCID: PMC1540753  PMID: 301448

Abstract

Phytohaemagglutinin-induced lymphocyte transformation and circulating thymus-dependent (T) lymphocyte numbers were studied in twenty-eight patients with systemic sclerosis (SS), in fifty normal controls and eleven elderly controls. Patients with SS were found to have impaired lymphocyte transformation responses which showed a positive correlation with both the number of circulating T lymphocytes and the extent of visceral involvement by the disease. This defect of cell-mediated immunity could not be attributed to the effects of increasing age, corticosteroid treatment, iron and folate deficiency or inhibitory serum factors and may have pathogenetic implications for the disorder.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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