Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1977 May;28(2):352–358.

The genetic contribution of the NZB mouse to the renal disease of the NZB x NZW hybrid.

J G Knight, D D Adams, H D Purves
PMCID: PMC1540763  PMID: 872452

Abstract

The occurrence of lupus nephritis in (NZB x NZW)F1 mice appears to depend on the action of at least two dominant or co-dominant genes (at least one gene from each parent) as neither of the inbred parental strains shows the disorder. Identifying affected animals by antemortem determinations of renal function, using improved methods of measuring proteinuria and renal clearance, we have studied the incidence of the renal disease in 230 (NZB x NZW)F1 x NZW backcross mice. The incidence was 49-6% which indicates that NZB strain contributes only one gene, or cluster of closely linked genes, to the renal disorder of the F1 hybrid. The gene(s) must be dominant or co-dominant, as it expresses its effect in the heterozygous state. Study of the H-2 status of the backcross mice showed a loose linkage of the NZB renal disease gene(s) to the D end of the H-2 complex, the crossover frequency being 32-6+/-3-1%.

Full text

PDF
352

Images in this article

353Fig. 1
on p.353

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AARONS I. RENAL IMMUNOFLUORESCENCE IN NZB-NZW MICE. Nature. 1964 Sep 5;203:1080–1081. doi: 10.1038/2031080a0. [DOI] [PubMed] [Google Scholar]
  2. BIELSCHOWSKY M., BIELSCHOWSKY F. OBSERVATIONS ON NZB/B1 MICE; DIFFERENTIAL FERTILITY IN RECIPROCAL CROSSES AND THE TRANSMISSION OF THE AUTO-IMMUNE HAEMOLYTIC ANAEMIA TO NZB/B1 X NZC/B1 HYBRIDS. Aust J Exp Biol Med Sci. 1964 Aug;42:561–568. [PubMed] [Google Scholar]
  3. BURCH P. R., ROWELL N. R. SYSTEMIC LUPUS ERYTHEMATOSUS: ETIOLOGICAL ASPECTS. Am J Med. 1965 May;38:793–801. doi: 10.1016/0002-9343(65)90199-3. [DOI] [PubMed] [Google Scholar]
  4. Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
  5. Braverman I. M. Study of autoimmune disease in New Zealand mice. I. Genetic features and natural history of NZB, NZY and NZW strains and NZB-NZW hybrids. J Invest Dermatol. 1968 Jun;50(6):483–499. doi: 10.1038/jid.1968.79. [DOI] [PubMed] [Google Scholar]
  6. Brien T. G., Fay J. A. 51 Cr-EDTA biological half life as an index of renal function. J Nucl Med. 1972 May;13(5):339–340. [PubMed] [Google Scholar]
  7. Burnet M., Holmes M. C. Genetic investigations of autoimmune disease in mice. Nature. 1965 Jul 24;207(995):368–371. doi: 10.1038/207368a0. [DOI] [PubMed] [Google Scholar]
  8. Cunningham A. J. The generation of antibody diversity: its dependence on antigenic stimulation. Contemp Top Mol Immunol. 1974;3:1–26. doi: 10.1007/978-1-4684-2838-4_1. [DOI] [PubMed] [Google Scholar]
  9. GIBSON J. G., 2nd, REES S. B., McMANUS T. J., SCHEITLIN W. A. A cltrate-phosphatedextrose solution for the preservation of human blood. Am J Clin Pathol. 1957 Dec;28(6):569–578. doi: 10.1093/ajcp/28.6.569. [DOI] [PubMed] [Google Scholar]
  10. Gally J. A., Edelman G. M. The genetic control of immunoglobulin synthesis. Annu Rev Genet. 1972;6:1–46. doi: 10.1146/annurev.ge.06.120172.000245. [DOI] [PubMed] [Google Scholar]
  11. Ghaffar A., Playfair J. H. The genetic basis of autoimmunity in NZB mice studied by progeny-testing. Clin Exp Immunol. 1971 Mar;8(3):479–490. [PMC free article] [PubMed] [Google Scholar]
  12. HERZENBERG L. A., WARNER N. L., HERZENBERG L. A. IMMUNOGLOBULIN ISOANTIGENS (ALLOTYPES) IN THE MOUSE. I. GENETICS AND CROSS-REACTIONS OF THE 7S GAMMA-2A-ISOANTIGENS CONTROLLED BY ALLELES AT THE IG-1 LOCUS. J Exp Med. 1965 Mar 1;121:415–438. doi: 10.1084/jem.121.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HOLMES M. C., BURNET F. M. THE INHERITANCE OF AUTOIMMUNE DISEASE IN MICE: A STUDY OF HYBRIDS OF THE STRAINS NZB AND C3H. Heredity (Edinb) 1964 Aug;19:419–434. doi: 10.1038/hdy.1964.52. [DOI] [PubMed] [Google Scholar]
  14. Hall W. H., Simpson L. O. The origins of some hitherto undescribed inbred mouse strains. Lab Anim. 1975 Apr;9(2):139–142. doi: 10.1258/002367775780994754. [DOI] [PubMed] [Google Scholar]
  15. Holmes M. C., Burnet F. M. The characteristics of F1 and backcross hybrids between "high leukaemia" (AKR) and "autoimmune" (NZB) mouse strains. Aust J Exp Biol Med Sci. 1966 Jun;44(3):235–249. doi: 10.1038/icb.1966.24. [DOI] [PubMed] [Google Scholar]
  16. Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
  17. JACOB F., MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318–356. doi: 10.1016/s0022-2836(61)80072-7. [DOI] [PubMed] [Google Scholar]
  18. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Laurell C. B. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem. 1966 Apr;15(1):45–52. doi: 10.1016/0003-2697(66)90246-6. [DOI] [PubMed] [Google Scholar]
  20. Lotzová E., Cudkowicz G. Resistance of irradiated F 1 hybrid and allogeneic mice to bone marrow grafts of NZB donors. J Immunol. 1973 Mar;110(3):791–800. [PubMed] [Google Scholar]
  21. Orellana-Alcalde J. M., Dominguez J. P. Jaundice and oral contraceptive drugs. Lancet. 1966 Dec 10;2(7476):1279–1280. [PubMed] [Google Scholar]
  23. SAPIRSTEIN L. A., VIDT D. G., MANDEL M. J., HANUSEK G. Volumes of distribution and clearances of intravenously injected creatinine in the dog. Am J Physiol. 1955 May;181(2):330–336. doi: 10.1152/ajplegacy.1955.181.2.330. [DOI] [PubMed] [Google Scholar]
  24. Weigert M. G., Cesari I. M., Yonkovich S. J., Cohn M. Variability in the lambda light chain sequences of mouse antibody. Nature. 1970 Dec 12;228(5276):1045–1047. doi: 10.1038/2281045a0. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES