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. 1977 May;28(2):197–203.

Rheumatoid factor plaque-forming cells in rheumatoid synovial tissue.

M M Taylor-Upsahl, T G Abrahamsen, J B Natvig
PMCID: PMC1540764  PMID: 326444

Abstract

Cells producing rheumatoid factor (RF) were readily detected in vitro by means of a haemolytic plaque assay system employing sheep erythrocytes (SRBC) sensitized with reduced and alkylated rabbit IgG anti-SRBC antibody as target cells. Rheumatoid factor-producing, plaque-forming cells (RF-PFC) were observed in all of the synovial tissue cell preparations from seropositive rheumatoid arthritis patients studied. The numbers of RF-PFC varied considerably without any direct correlation with serum titres of RF antibody activity. However, high numbers of RF-PFC were never found in patients with low rheumatoid factor titres whereas, high and low numbers of RF-PFC were found among the patients with high RF titres. Synovial tissue cell preparations from a group of seronegative patients, with only one exception, failed to exhibit RF-PFC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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