Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1976 Oct;26(1):129–132.

Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients.

G A Rook, J W Carswell, J L Stanford
PMCID: PMC1540826  PMID: 826362

Abstract

Lymphocyte-transformation responses to mycobacterial antigens have been studied, using paired blood and lymph node samples from 'normal' Ugandans, (hernia repairs or orthopaedic cases) or from patients with tuberculosis, Mycobacterium ulcerans infection, or injection abscesses. The results suggest that in some individuals, antigen reactive cells, although absent from the periphery, may be demonstrable in the lymph nodes. This phenomenon is most striking in skin-test negative tuberculosis patients.

Full text

PDF
129

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ford W. L., Atkins R. C. Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats. Nat New Biol. 1971 Dec 8;234(49):178–180. doi: 10.1038/newbio234178a0. [DOI] [PubMed] [Google Scholar]
  2. McConnell I., Lachmann P. J., Hobart M. J. Restoration of specific immunological virginity. Nature. 1974 Jul 12;250(462):113–116. doi: 10.1038/250113a0. [DOI] [PubMed] [Google Scholar]
  3. Myrvang B., Godal T., Ridley D. S., Fröland S. S., Song Y. K. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin Exp Immunol. 1973 Aug;14(4):541–553. [PMC free article] [PubMed] [Google Scholar]
  5. Paul R. C., Stanford J. L., Misljenóvic O., Lefering J. Multiple skin testing of Kenyan schoolchildren with a series of new tuberculins. J Hyg (Lond) 1975 Oct;75(2):303–313. doi: 10.1017/s002217240004732x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Rook G. A. The immunological consequences of antigen overload in experimental mycobacterial infections of mice. Clin Exp Immunol. 1975 Jan;19(1):167–177. [PMC free article] [PubMed] [Google Scholar]
  7. Rook G. A. The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products. Clin Exp Immunol. 1975 Jul;21(1):163–172. [PMC free article] [PubMed] [Google Scholar]
  8. Rowley D. A., Gowans J. L., Atkins R. C., Ford W. L., Smith M. E. The specific selection of recirculating lymphocytes by antigen in normal and preimmunized rats. J Exp Med. 1972 Sep 1;136(3):499–513. doi: 10.1084/jem.136.3.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Schlossman S. F., Levin H. A., Rocklin R. E., David J. R. The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs. J Exp Med. 1971 Sep 1;134(3 Pt 1):741–750. doi: 10.1084/jem.134.3.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sprent J., Miller J. F., Mitchell G. F. Antigen-induced selective recruitment of circulating lymphocytes. Cell Immunol. 1971 Apr;2(2):171–181. doi: 10.1016/0008-8749(71)90036-0. [DOI] [PubMed] [Google Scholar]
  11. Stanford J. L., Paul R. C. A preliminary report on some studies of environmental mycobacteria. Ann Soc Belg Med Trop. 1973;53(4):389–393. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES