Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1977 Jan;27(1):143–151.

Ecotaxis: the principle and its application to the study of Hodgkin's disease.

M D Sousa, M Yang, E Lopes-Corrales, C Tan, J A Hansen, B Dupont, R A Good
PMCID: PMC1540896  PMID: 300302

Abstract

A study of the function, characterization and distribution of T and B lymphocytes in five children with Hodgkin's disease is presented. The results, indicating that lymphocyte depletion in the peripheral blood does not necessarily reflect an overall lack of circulating lymphocytes, are presented to demonstrate that failure of ecotaxis (normal lymphocyte migration and distribution) can occur in man. The underlying reasons for such failure and their relevance to the pathogenesis of Hodgkin's disease are discussed.

Full text

PDF
143

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen E. Depletion of thymus dependent lymphocytes in Hodgkin's disease. Scand J Haematol. 1974;12(4):263–269. doi: 10.1111/j.1600-0609.1974.tb00208.x. [DOI] [PubMed] [Google Scholar]
  2. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bobrove A. M., Fuks Z., Strober S., Kaplan H. S. Quantitation of T and B lymphocytes and cellular immune function in Hodgkin's disease. Cancer. 1975 Jul;36(1):169–179. doi: 10.1002/1097-0142(197507)36:1<169::aid-cncr2820360115>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  4. Eltringham J. R., Kaplan H. S. Impaired delayed-hypersensitivity responses in 154 patients with untreated Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:107–115. [PubMed] [Google Scholar]
  5. Eshhar Z., Order S. E., Katz D. H. Ferritin, a Hodgkin's disease associated antigen. Proc Natl Acad Sci U S A. 1974 Oct;71(10):3956–3960. doi: 10.1073/pnas.71.10.3956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ford W. L., Gowans J. L. The traffic of lymphocytes. Semin Hematol. 1969 Jan;6(1):67–83. [PubMed] [Google Scholar]
  7. Ford W. L. Lymphocyte migration and immune responses. Prog Allergy. 1975;19:1–59. doi: 10.1159/000313381. [DOI] [PubMed] [Google Scholar]
  8. Freitas A. A., de Sousa M. Control mechanism of lymphocyte traffic. Altered distribution of 51Cr-labeled mouse lymph node cells pretreated in vitro with lipopolysaccharide. Eur J Immunol. 1976 Apr;6(4):269–273. doi: 10.1002/eji.1830060407. [DOI] [PubMed] [Google Scholar]
  9. Freitas A. A., de Sousa M. The role of cell interactions in the control of lymphocyte traffic. Cell Immunol. 1976 Mar 15;22(2):345–350. doi: 10.1016/0008-8749(76)90035-6. [DOI] [PubMed] [Google Scholar]
  10. GOWANS J. L. The recirculation of lymphocytes from blood to lymph in the rat. J Physiol. 1959 Apr 23;146(1):54–69. doi: 10.1113/jphysiol.1959.sp006177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gajl-Peczalska K. J., Hansen J. A., Bloomfield C. D., Good R. A. B lymphocytes in untreated patients with malignant lymphoma and Hodgkin's disease. J Clin Invest. 1973 Dec;52(12):3064–3073. doi: 10.1172/JCI107505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Grifoni V. Recent immunological findins in Hodgkin's disease. Tumori. 1973 Sep-Oct;59(5):363–373. doi: 10.1177/030089167305900508. [DOI] [PubMed] [Google Scholar]
  13. Habeshaw J. A., Young G. A. Quantitation of subclasses of mononuclear cells in normal human blood by membrane receptor studies. Br J Haematol. 1975 Jan;29(1):43–55. doi: 10.1111/j.1365-2141.1975.tb01798.x. [DOI] [PubMed] [Google Scholar]
  14. Kaur J., Spiers A. S., Catovsky D., Galton D. A. Increase of T lymphocytes in the spleen in Hodgkin's disease. Lancet. 1974 Oct 5;2(7884):800–802. doi: 10.1016/s0140-6736(74)91070-8. [DOI] [PubMed] [Google Scholar]
  15. Lang J. M., Oberling F., Bigel P., Mayer S., Waitz R. Lymphocyte reactivity to phytohaemagglutinin and allogeneic lymphocytes in 32 untreated patients with Hodgkin's disease. Biomedicine. 1974 Sep 20;21(9):372–377. [PubMed] [Google Scholar]
  16. Levy R., Kaplan H. S. Impaired lymphocyte function in untreated Hodgkin's disease. N Engl J Med. 1974 Jan 24;290(4):181–186. doi: 10.1056/NEJM197401242900402. [DOI] [PubMed] [Google Scholar]
  17. MacKie R., Sless F. R., Cochran R., De Sousa M. Lymphocyte abnormalities in mycosis fungoides. Br J Dermatol. 1976 Feb;94(2):173–178. doi: 10.1111/j.1365-2133.1976.tb04367.x. [DOI] [PubMed] [Google Scholar]
  18. Matchett K. M., Huang A. T., Kremer W. B. Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes. J Clin Invest. 1973 Aug;52(8):1908–1917. doi: 10.1172/JCI107374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Nordqvist B. C., Kinney J. P. T and B cells and cell-mediated immunity in mycosis fungoides. Cancer. 1976 Feb;37(2):714–718. doi: 10.1002/1097-0142(197602)37:2<714::aid-cncr2820370216>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  20. Parrott D. M., De Sousa M. Thymus-dependent and thymus-independent populations: origin, migratory patterns and lifespan. Clin Exp Immunol. 1971 May;8(5):663–684. [PMC free article] [PubMed] [Google Scholar]
  21. Payne S. V., Jones D. B., Haegert D. G., Smith J. L., Wright D. H. T and B lymphocytes and Reed-Sternberg cells in Hodgkin's disease lymph nodes and spleens. Clin Exp Immunol. 1976 May;24(2):280–286. [PMC free article] [PubMed] [Google Scholar]
  22. de Sousa M. Kinetics of the distribution of thymus and marrow cells in the peripheral lymphoid organs of the mouse: ecotaxis. Clin Exp Immunol. 1971 Sep;9(3):371–380. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES