Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1977 Mar;27(3):502–506.

Levamisole augments the cytotoxic T-cell response depending on the dose of drugs and antigen administered.

R B Faanes, P Dillon, Y S Choi
PMCID: PMC1540944  PMID: 405166

Abstract

The effects of levamisole on the immune of cytotoxic thymus-derived lymphocytes were studied. An optimum relative dose of antigen and and lavamisole appears to be crucial for levamisole to augment development of cytotoxic cells.

Full text

PDF
502

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berke G., Sullivan K. A., Amos B. Rejection of ascites tumor allografts. I. Isolation, characterization, and in vitro reactivity of peritoneal lymphoid effector cells from BALB-c mice immune to EL4 leukosis. J Exp Med. 1972 Jun 1;135(6):1334–1350. doi: 10.1084/jem.135.6.1334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brunner K. T., Mauel J., Rudolf H., Chapuis B. Studies of allograft immunity in mice. I. Induction, development and in vitro assay of cellular immunity. Immunology. 1970 Apr;18(4):501–515. [PMC free article] [PubMed] [Google Scholar]
  3. Cerottini J. C., Brunner K. T. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol. 1974;18:67–132. doi: 10.1016/s0065-2776(08)60308-9. [DOI] [PubMed] [Google Scholar]
  4. Chirigos M. A., Pearson J. W., Pryor J. Augmentation of chemotherapeutically induced remission of a murine leukemia by a chemical immunoadjuvant. Cancer Res. 1973 Nov;33(11):2615–2618. [PubMed] [Google Scholar]
  5. Faanes R. B., Choi Y. S., Good R. A. Escape from isoantiserum inhibition of lymphocyte-mediated cytotoxicity. J Exp Med. 1973 Jan 1;137(1):171–182. doi: 10.1084/jem.137.1.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ghaffar A., Cullen R. T., Woodruff M. A. Further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with Corynebacterium parvum. Br J Cancer. 1975 Jan;31(1):15–24. doi: 10.1038/bjc.1975.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lichtenfeld J. L., Desner M. R., Wiernik P. H., Mardiney M. R., Jr Modulating effects of levamisole (NSC-177023) on human lymphocyte response in vitro. Cancer Treat Rep. 1976 May;60(5):571–574. [PubMed] [Google Scholar]
  8. Mackaness G. B., Lagrange P. H. Restoration of cell-mediated immunity to animals blocked by a humoral response. J Exp Med. 1974 Sep 1;140(3):865–870. doi: 10.1084/jem.140.3.865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mantovani A., Spreafico F. Allogeneic tumor enhancement by levamisole, a new immunostimulatory compound: studies on cell-mediated immunity and humoral antibody response. Eur J Cancer. 1975 Aug;11(8):537–544. doi: 10.1016/0014-2964(75)90125-5. [DOI] [PubMed] [Google Scholar]
  10. Potter C. W., Carr I., Jennings R., Rees R. C., McGinty F., Richardson V. M. Levamisole inactive in treatment of four animal tumours. Nature. 1974 Jun 7;249(457):567–569. doi: 10.1038/249567a0. [DOI] [PubMed] [Google Scholar]
  11. Renoux G., Renoux M. Action immunostimulante de dérivés du phénylimidothiazole sur les cellules spléniques formatrices d'anticorps. C R Acad Sci Hebd Seances Acad Sci D. 1972 Jan 31;274(5):756–757. [PubMed] [Google Scholar]
  12. Renoux G., Renoux M. Levamisole inhibits and cures a solid malignant tumour and its pulmonary metastases in mice. Nat New Biol. 1972 Dec 13;240(102):217–218. doi: 10.1038/newbio240217a0. [DOI] [PubMed] [Google Scholar]
  13. Renoux G., Renoux M. Modulation of immune reactivity by phenylimidothiazole salts in mice immunized by sheep red blood cells. J Immunol. 1974 Sep;113(3):779–790. [PubMed] [Google Scholar]
  14. Scott M. T. Corynebacterium parvum as a therapeutic antitumor agent in mice. I. Systemic effects from intravenous injection. J Natl Cancer Inst. 1974 Sep;53(3):855–860. doi: 10.1093/jnci/53.3.855. [DOI] [PubMed] [Google Scholar]
  15. Spreafico F., Vecchi A., Mantovani A., Poggi A., Franchi G., Anaclerio A., Garattini S. Characterization of the immunostimulants levamisole and tetramisole. Eur J Cancer. 1975 Aug;11(8):555–563. doi: 10.1016/0014-2964(75)90127-9. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES