Abstract
Trypanosoma musculi produces a resolving infection in mice and the immune response is thymus dependent. Spleen cells from immune and from uninfected mice were transferred to T cell-deprived mice and restored their ability to control the infection, the immune cells being effective most rapidly. Treatment of the cells in vitro with anti-theta serum did not impair their ability to restore immunocompetence and it is proposed that, though T-cell dependent, the immune response is effected by theta- cells.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CUNNINGHAM M. P., LUMSDEN W. H., WEBBER W. A. PRESERVATION OF VIABLE TRYPANOSOMES IN LYMPH TUBES AT LOW TEMPERATURE. Exp Parasitol. 1963 Dec;14:280–284. doi: 10.1016/0014-4894(63)90032-8. [DOI] [PubMed] [Google Scholar]
- Cohen A., Schlesinger M. Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells. Transplantation. 1970 Jul;10(1):130–132. doi: 10.1097/00007890-197007000-00027. [DOI] [PubMed] [Google Scholar]
- Golub E. S. Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells. Cell Immunol. 1971 Aug;2(4):353–361. doi: 10.1016/0008-8749(71)90070-0. [DOI] [PubMed] [Google Scholar]
- Kataoka Y., Sado T. The radiosensitivity of T and B lymphocytes in mice. Immunology. 1975 Jul;29(1):121–130. [PMC free article] [PubMed] [Google Scholar]
- Kerbel R. S., Elliott E. V., Wallis V. J. Assessment of mitotic thymus-derived lymphocytes by their sensitivity to the cytotoxic effects of anti-theta serum. Cell Immunol. 1974 Mar 30;11(1-3):146–161. doi: 10.1016/0008-8749(74)90015-x. [DOI] [PubMed] [Google Scholar]
- Krampitz H. E. Verbreitung, Wirt-Parasit-Beziehungen und Vermehrung sizilianischer Stämme von Trypanosoma (H erpetosoma) duttoni Thiroux, 1905 (Protozoa, Trypanosomatidae) Z Parasitenkd. 1969;32(4):297–315. doi: 10.1007/BF00259643. [DOI] [PubMed] [Google Scholar]
- Lamvik J. O. Separation of lymphocytes from human blood. Acta Haematol. 1966 May;35(5):294–303. doi: 10.1159/000209135. [DOI] [PubMed] [Google Scholar]
- Miller J. F., Sprent J. Thymus-derived cells in mouse thoracic duct lymph. Nat New Biol. 1971 Apr 28;230(17):267–270. doi: 10.1038/newbio230267a0. [DOI] [PubMed] [Google Scholar]
- REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raff M. C. Surface antigenic markers for distinguishing T and B lymphocytes in mice. Transplant Rev. 1971;6:52–80. doi: 10.1111/j.1600-065x.1971.tb00459.x. [DOI] [PubMed] [Google Scholar]
- Raff M. C. Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence. Immunology. 1970 Oct;19(4):637–650. [PMC free article] [PubMed] [Google Scholar]
- Raff M. Theta isoantigen as a marker of thymus-derived lymphocytes in mice. Nature. 1969 Oct 25;224(5217):378–379. doi: 10.1038/224378a0. [DOI] [PubMed] [Google Scholar]
- Targett G. A., Viens P. The immunological response of CBA mice to Trypanosoma musculi: elimination of the parasite from the blood. Int J Parasitol. 1975 Apr;5(2):231–234. doi: 10.1016/0020-7519(75)90034-x. [DOI] [PubMed] [Google Scholar]
- Viens P., Pouliot P., Targett G. A. Cell-mediated immunity during the infection of CBA mice with Trypanosoma musculi. Can J Microbiol. 1974 Jan;20(1):105–106. doi: 10.1139/m74-016. [DOI] [PubMed] [Google Scholar]
- Viens P., Targett G. A., Leuchars E., Davies A. J. The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation. Clin Exp Immunol. 1974 Feb;16(2):279–294. [PMC free article] [PubMed] [Google Scholar]
