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. 1976 Dec;26(3):511–519.

Immune function in sarcoidosis. Studies on delayed hypersensitivity, B and T lymphocytes, serum immunoglobulins and serum complement components.

H Tannenbaum, R E Rocklin, P H Schur, A L Sheffer
PMCID: PMC1540971  PMID: 795577

Abstract

An assessment of immune function was performed in twenty-four patients with recently diagnosed active sarcoidosis. Four patients manifested skin anergy to four antigens. All subjects except one were capable of generating a positive skin response to a croton oil patch test. The incorporation of [3H]thymidine by lymphocytes in vitro in response to the nonspecific mitogens--phytohaemagglutinin, pokeweed mitogen and Con A did not differ between anergic and non-anergic thymidine incorporation in vitro when stimulated by the specific antigens, streptokinase/streptodornase or Candida albicans. Lymphocytes obtained from nine of eleven patients having positive delayed hypersensitivity skin reactions demonstrated MIF production in vitro upon specific antigen challenge. Quantities of circulating B and T lymphocytes did not differ between anergic and absolute numbers of circulating B and T lymphocytes, as well as hypercomplementaemia and hypergammaglobulinaemia when compared to the control group.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belcher R. W., Carney J. F., Nankervis G. A. Effect of sera from patients with sarcoidosis on in vitro lymphocyte response. Int Arch Allergy Appl Immunol. 1974;46(2):183–190. doi: 10.1159/000231122. [DOI] [PubMed] [Google Scholar]
  2. Biberfeld P., Hedfors E. Atypical blood lymphocytes in sarcoidosis: morphology, cytochemistry, and membrane properties. Scand J Immunol. 1974;3(5):615–625. doi: 10.1111/j.1365-3083.1974.tb01295.x. [DOI] [PubMed] [Google Scholar]
  3. Buckley C. E., 3rd, Nagaya H., Sieker H. O. Altered immunologic activity in sarcoidosis. Ann Intern Med. 1966 Mar;64(3):508–520. doi: 10.7326/0003-4819-64-3-508. [DOI] [PubMed] [Google Scholar]
  4. Buckley C. E., Trayer H. R. Serum IgD concentrations in sarcoidosis and tuberculosis. Clin Exp Immunol. 1972 Feb;10(2):257–265. [PMC free article] [PubMed] [Google Scholar]
  5. COWLING D. C., QUAGLINO D., BARRETT P. K. EFFECT OF KVEIM ANTIGEN AND OLD TUBERCULIN ON LYMPHOCYTES IN CULTURE FROM SARCOID PATIENTS. Br Med J. 1964 Jun 6;1(5396):1481–1482. doi: 10.1136/bmj.1.5396.1481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Douglas S. D., Schmidt M. E., Siltzbach L. E. Monocyte receptor activity in normal individuals and patients with sarcoidosis. Immunol Commun. 1972;1(1):25–38. doi: 10.3109/08820137209022890. [DOI] [PubMed] [Google Scholar]
  7. Girard J. P., Poupon M. F., Press P. Culture of peripheral blood lymphocytes from sarcoidosis; response to mitogenic factor. Int Arch Allergy Appl Immunol. 1971;41(4):604–619. doi: 10.1159/000230553. [DOI] [PubMed] [Google Scholar]
  8. HIRSCHHORN K., SCHREIBMAN R. R., BACH F. H., SILTZBACH L. E. IN-VITRO STUDIES OF LYMPHOCYTES FROM PATIENTS WITH SARCOIDOSIS AND LYMPHOPROLIFERATIVE DISEASES. Lancet. 1964 Oct 17;2(7364):842–843. doi: 10.1016/s0140-6736(64)90691-9. [DOI] [PubMed] [Google Scholar]
  9. Hedfors E., Holm G., Pettersson D. Lymphocyte subpopulations in sarcoidosis. Clin Exp Immunol. 1974 Jun;17(2):219–226. [PMC free article] [PubMed] [Google Scholar]
  10. Hedfors E. Immunological aspects of sarcoidosis. Scand J Respir Dis. 1975 May;56(1):1–19. [PubMed] [Google Scholar]
  11. Hedfors E., Norberg R. Evidence for circulating immune complexes in sarcoidosis. Clin Exp Immunol. 1974 Mar;16(3):493–496. [PMC free article] [PubMed] [Google Scholar]
  12. Horsmanheimo M., Virolainen M. Correlation of phytohaemagglutinin-induced lymphocyte transformation with clinical manifestations of sarcoidosis. Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Feb;82(1):122–126. doi: 10.1111/j.1699-0463.1974.tb02302.x. [DOI] [PubMed] [Google Scholar]
  13. James D. G., Neville E., Walker A. Immunology of sarcoidosis. Am J Med. 1975 Sep;59(3):388–394. doi: 10.1016/0002-9343(75)90397-6. [DOI] [PubMed] [Google Scholar]
  14. KENT J. F., FIFE E. H., Jr Precise standardization of reagents for complement fixation. Am J Trop Med Hyg. 1963 Jan;12:103–116. doi: 10.4269/ajtmh.1963.12.103. [DOI] [PubMed] [Google Scholar]
  15. Kataria Y. P., Sagone A. L., LoBuglio A. G., Bromberg P. A. In vitro observations on sarcoid lymphocytes and their correlation with cutaneous energy and clinical severity of disease. Am Rev Respir Dis. 1973 Oct;108(4):767–776. doi: 10.1164/arrd.1973.108.4.767. [DOI] [PubMed] [Google Scholar]
  16. Langner A., Moskalewska K., Proniewska M. Studies on the mechanism of lymphocyte transformation inhibition in sarcoidosis. Br J Dermatol. 1969 Nov;81(11):829–834. doi: 10.1111/j.1365-2133.1969.tb15952.x. [DOI] [PubMed] [Google Scholar]
  17. Lewis E. J., Carpenter C. B., Schur P. H. Serum complement component levels in human glomerulonephritis. Ann Intern Med. 1971 Oct;75(4):555–560. doi: 10.7326/0003-4819-75-4-555. [DOI] [PubMed] [Google Scholar]
  18. Mangi R. J., Dwyer J. M., Gee B., Kantor F. S. The immunological competence of subjects with sarcoidosis. Clin Exp Immunol. 1974 Dec;18(4):505–517. [PMC free article] [PubMed] [Google Scholar]
  19. Mangi R. J., Dwyer J. M., Kantor F. S. The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis. Clin Exp Immunol. 1974 Dec;18(4):519–528. [PMC free article] [PubMed] [Google Scholar]
  20. Papamichail M., Brown J. C., Holborow E. J. Immunoglobulins on the surface of human lymphocytes. Lancet. 1971 Oct 16;2(7729):850–852. doi: 10.1016/s0140-6736(71)90224-8. [DOI] [PubMed] [Google Scholar]
  21. Rocklin R. E., MacDermott R. P., Chess L., Schlossman S. F., David J. R. Studies on mediator production by highly purified human T and B lymphocytes. J Exp Med. 1974 Nov 1;140(5):1303–1316. doi: 10.1084/jem.140.5.1303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Schur P. H., Borel H., Gelfand E. W., Alper C. A., Rosen F. S. Selective gamma-g globulin deficiencies in patients with recurrent pyogenic infections. N Engl J Med. 1970 Sep 17;283(12):631–634. doi: 10.1056/NEJM197009172831205. [DOI] [PubMed] [Google Scholar]
  23. Sharma O. P., James D. G., Fox R. A. A correlation of in vivo delayed-type hypersensitivity with in vitro lymphocyte transformation in sarccidosis. Chest. 1971 Jul;60(1):35–37. doi: 10.1378/chest.60.1.35. [DOI] [PubMed] [Google Scholar]
  24. Sheffer A. L., Rocklin R. E., Goetzl E. J. Immunologic components of hypersensitivity reactions to cromolyn sodium. N Engl J Med. 1975 Dec 11;293(24):1220–1224. doi: 10.1056/NEJM197512112932402. [DOI] [PubMed] [Google Scholar]
  25. Tannenbaum H., Pinkus G. S., Anderson L. G., Schur P. H. Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren's syndrome. Arthritis Rheum. 1975 Jul-Aug;18(4):305–314. doi: 10.1002/art.1780180403. [DOI] [PubMed] [Google Scholar]
  26. Topilsky M., Siltzbach L. E., Williams M., Glade P. R. Lymphocyte response in sarcoidosis. Lancet. 1972 Jan 15;1(7742):117–120. doi: 10.1016/s0140-6736(72)90680-0. [DOI] [PubMed] [Google Scholar]
  27. Yagura T., Shimizu M., Yamamura Y., Tachibana T. Serum IgE levels and reaginic-type skin reactions in sarcoidosis. Clin Exp Immunol. 1975 Aug;21(2):289–297. [PMC free article] [PubMed] [Google Scholar]

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