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. 1977 Jun;28(3):453–457.

Lymphocyte populations in peripheral blood during normal human pregnancy.

M G Baines, H F Pross, K G Millar
PMCID: PMC1541014  PMID: 330056

Abstract

The effects of normal pregnancy on peripheral blood lymphocytes were investigated. The frequencies of thymus-derived and bone-marrow-derived lymphocytes in maternal peripheral blood does not vary significantly throughout pregnancy. This observation implies qualitative rather than quantitative alterations in lymphocyte functions to explain the reduced cell-mediated immune responses seen during pregnancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baines M. G., Ansell J., McLaren A., Micklem H. S. Maternal immunization to paternal antigens in multiparous mice. J Reprod Fertil. 1975 Feb;42(2):293–299. doi: 10.1530/jrf.0.0420293. [DOI] [PubMed] [Google Scholar]
  2. Baines M. G., Speers E. A., Pross H., Millar K. G. Characteristics of the maternal lymphoid response of mice to paternal strain antigens induced by homologous pregnancy. Immunology. 1976 Sep;31(3):363–369. [PMC free article] [PubMed] [Google Scholar]
  3. Boyle W. An extension of the 51Cr-release assay for the estimation of mouse cytotoxins. Transplantation. 1968 Sep;6(6):761–764. doi: 10.1097/00007890-196809000-00002. [DOI] [PubMed] [Google Scholar]
  4. Carter J. The effect of progesterone, oestradiol and HCG on cell-mediated immunity in pregnant mice. J Reprod Fertil. 1976 Jan;46(1):211–216. doi: 10.1530/jrf.0.0460211. [DOI] [PubMed] [Google Scholar]
  5. EFRATI P., PRESENTEY B., MARGALITH M., ROZENSZAJN L. LEUKOCYTES OF NORMAL PREGNANT WOMEN. Obstet Gynecol. 1964 Mar;23:429–432. [PubMed] [Google Scholar]
  6. EICKHOFF T. C., SHERMAN I. L., SERFLING R. E. Observations on excess mortality associated with epidemic influenza. JAMA. 1961 Jun 3;176:776–782. doi: 10.1001/jama.1961.03040220024005. [DOI] [PubMed] [Google Scholar]
  7. Fabris N. Immunological reactivity during pregnancy in the mouse. Experientia. 1973 May 15;29(5):610–612. doi: 10.1007/BF01926697. [DOI] [PubMed] [Google Scholar]
  8. Golub S. H., O'Connell T. X., Morton D. L. Correlation of in vivo and in vitro assays of immunocompetence in cancer patients. Cancer Res. 1974 Aug;34(8):1833–1837. [PubMed] [Google Scholar]
  9. Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
  10. Jenkins V. K., Olson M. H., Ellis H. N., Dillard E. A., Jr In vitro lymphocyte response of patients with uterine cancer as related to clinical stage and radiotherapy. Gynecol Oncol. 1975 Sep;3(3):191–200. doi: 10.1016/s0090-8258(75)80002-3. [DOI] [PubMed] [Google Scholar]
  11. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jones E., Curzen P., Gaugas J. M. Suppressive activity of pregnancy plasma on the mixed lymphocyte reaction. J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):603–607. doi: 10.1111/j.1471-0528.1973.tb16033.x. [DOI] [PubMed] [Google Scholar]
  13. Loke Y. W., Brook S. S., Allen G. E. Increase in IgM-bearing lymphocytes in peripheral blood of pregnant women. Am J Obstet Gynecol. 1975 Jul 1;122(5):561–564. doi: 10.1016/0002-9378(75)90049-6. [DOI] [PubMed] [Google Scholar]
  14. Lonai P., Feldman M. Cooperation of lymphoid cells in an in vitro graft reaction system. The role of the thymus cell. Transplantation. 1970 Nov;10(5):372–381. doi: 10.1097/00007890-197011000-00003. [DOI] [PubMed] [Google Scholar]
  15. Millar K. G., Mills P., Baines M. G. A study of the influence of pregnancy on the thymus gland of the mouse. Am J Obstet Gynecol. 1973 Dec 1;117(7):913–918. doi: 10.1016/0002-9378(73)90061-6. [DOI] [PubMed] [Google Scholar]
  16. Miller J. F., Brunner K. T., Sprent J., Russell P. J., Mitchell G. F. Thymus-derived cells as killer cells in cell-mediated immunity. Transplant Proc. 1971 Mar;3(1):915–917. [PubMed] [Google Scholar]
  17. Nelson J. H., Jr, Hall J. E., Manuel-Limson G., Freidberg H., O'Brien F. J. Effect of pregnancy on the thymolymphatic system. I. Changes in the intact rat after exogenous HCG, estrogen, and progesterone administration. Am J Obstet Gynecol. 1967 Aug 1;98(7):895–899. [PubMed] [Google Scholar]
  18. Olding L. B., Oldstone B. A. Thymus-derived peripheral lymphocytes from human newborns inhibit division of their mothers' lymphocytes. J Immunol. 1976 Mar;116(3):682–686. [PubMed] [Google Scholar]
  19. Pross H. F., Baines M. G. Spontaneous human lymphocyte-mediated cytotoxicity againts tumour target cells. I. The effect of malignant disease. Int J Cancer. 1976 Nov 15;18(5):593–604. doi: 10.1002/ijc.2910180508. [DOI] [PubMed] [Google Scholar]
  20. Searle R. F., Johnson M. H., Billington W. D., Elson J., Clutterbuck-Jackson S. Investigation of H-2 and non-H-2 antigens on the mouse blastocyst. Transplantation. 1974 Aug;18(2):136–141. doi: 10.1097/00007890-197408000-00006. [DOI] [PubMed] [Google Scholar]
  21. Strelkauskas A. J., Wilson B. S., Dray D., Dodson M. Inversion of levels of human T and B cells in early pregnancy. Nature. 1975 Nov 27;258(5533):331–332. doi: 10.1038/258331a0. [DOI] [PubMed] [Google Scholar]

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