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. 1977 Jun;28(3):502–505.

Antibodies against cytomegalovirus-induced early antigens (CMV-EA) in immunosuppressed renal-allograft recipients.

T H The, H K Andersen, E S Spencer, G Klein
PMCID: PMC1541019  PMID: 196800

Abstract

Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal implantation all showed CMV-EA antibody rises. Two patients remained seronegative until 4 years after transplantation. Thus, in immunosuppressed patients, antibodies against CMV-EA remained a high titres during many years (4--8 years) after transplantation as distinct from the apparently transient nature in acutely infected previously healthy adults with CMV mononucleosis or post-perfusion syndrome. These results support the view that CMV-EA antibodies reflect an active viral proliferation in the host.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen H. K. Cytomegalovirus neutralization by plaque reduction. Arch Gesamte Virusforsch. 1971;35(2):143–151. doi: 10.1007/BF01249705. [DOI] [PubMed] [Google Scholar]
  2. Andersen H. K., Spencer E. S. Cytomegalovirus infection among renal allograft recipients. Acta Med Scand. 1969 Jul-Aug;186(1-2):7–19. doi: 10.1111/j.0954-6820.1969.tb01432.x. [DOI] [PubMed] [Google Scholar]
  3. Craighead J. E., Hanshaw J. B., Carpenter C. B. Cytomegalovirus infection after renal allotransplantation. JAMA. 1967 Sep 4;201(10):725–728. [PubMed] [Google Scholar]
  4. Duvall C. P., Casazza A. R., Grimley P. M., Carbone P. P., Rowe W. P. Recovery of cytomegalovirus from adults with neoplastic disease. Ann Intern Med. 1966 Mar;64(3):531–541. doi: 10.7326/0003-4819-64-3-531. [DOI] [PubMed] [Google Scholar]
  5. Käriäinen L., Paloheimo J., Klemola E., Mäkelä T., Koivuniemi A. Cytomegalo virus--mononucleosis. Isolation of the virus and demonstration of subclinical infections after fresh blood transfusion in connection with open-heart surgery. Ann Med Exp Biol Fenn. 1966;44(2):297–301. [PubMed] [Google Scholar]
  6. Spencer E. S. Clinical aspects of cytomegalovirus infection in kidney-graft recipients. Scand J Infect Dis. 1974;6(4):315–323. doi: 10.3109/inf.1974.6.issue-4.04. [DOI] [PubMed] [Google Scholar]
  7. Stern H., Booth J. C., Elek S. D., Fleck D. G. Microbial causes of mental retardation. The role of prenatal infections with cytomegalovirus, rubella virus, and toxoplasma. Lancet. 1969 Aug 30;2(7618):443–448. doi: 10.1016/s0140-6736(69)90162-7. [DOI] [PubMed] [Google Scholar]
  8. The T. H., Klein G., Langenhuysen M. M. Antibody reactions to virus-specific early antigens (EA) in patients with cytomegalovirus (CMV) infection. Clin Exp Immunol. 1974 Jan;16(1):1-7,9-12. [PMC free article] [PubMed] [Google Scholar]
  9. WELLER T. H., HANSHAW J. B. Virologic and clinical observations on cytomegalic inclusion disease. N Engl J Med. 1962 Jun 14;266:1233–1244. doi: 10.1056/NEJM196206142662401. [DOI] [PubMed] [Google Scholar]
  10. Weller T. H. The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. I. N Engl J Med. 1971 Jul 22;285(4):203–214. doi: 10.1056/NEJM197107222850406. [DOI] [PubMed] [Google Scholar]

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