Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1977 Jul;29(1):61–66.

Immunobiology of primary intracranial tumours. II. Analysis of lymphocyte subpopulations in patients with primary brain tumours.

W H Brooks, T L Roszman, M S Mahaley, R E Woosley
PMCID: PMC1541043  PMID: 330067

Abstract

Circulating peripheral blood lymphocyte subpopulations were analysed in patients with primary intracranial neoplasia. Patients with tumours of glial origin demonstrated a significant depletion of E-rosetting lymphocytes whereas the quantitative lymphocyte profiles of patients with non-glial brain tumours were normal. The number of immunoglobulin and Fe receptor-bearing cells was not significantly altered in any group of patients: however, the EAC-RFC subpopulation was increased in those with malignant gliomas. Two hypotheses are suggested to explain these observations: first, the presence of cross-reacting antibody between T cells and brain (glial) cells, and secondly, the proliferation of EAC-RFC in response to malignant degeneration.

Full text

PDF
61

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anthony H. M., Kirk J. A., Madsen K. E., Mason M. K., Templeman G. H. E and EAC rosetting lymphocytes in patients with carcinoma of bronchus. II. A sequential study of thirty patients: effect of BCG. Clin Exp Immunol. 1975 Apr;20(1):41–54. [PMC free article] [PubMed] [Google Scholar]
  2. Arnaiz-Villena A., Hay F. C. Complement receptor lymphocytes. Analysis of immunoglobin on their surface and further evidence of heterogeneity. Immunology. 1975 Apr;28(4):719–729. [PMC free article] [PubMed] [Google Scholar]
  3. Brooks W. H., Caldwell H. D., Mortara R. H. Immune responses in patients with gliomas. Surg Neurol. 1974 Nov;2(6):419–423. [PubMed] [Google Scholar]
  4. Brooks W. H., Netsky M. G., Normansell D. E., Horwitz D. A. Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor. J Exp Med. 1972 Dec 1;136(6):1631–1647. doi: 10.1084/jem.136.6.1631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown G., Greaves M. F. Enumeration of absolute numbers of T and B lymphocytes in human blood. Scand J Immunol. 1974;3(2):161–172. doi: 10.1111/j.1365-3083.1974.tb01244.x. [DOI] [PubMed] [Google Scholar]
  6. Chess L., Levine H., MacDermott R. P., Schlossman S. F. Immunologic functions of isolated human lymphocyte subpopulations. VI. Further characterization of the surface Ig negative, E rosette negative (null cell) subset. J Immunol. 1975 Dec;115(6):1483–1487. [PubMed] [Google Scholar]
  7. Chiao J. W., Pantic V. S., Good R. A. Human lymphocytes bearing both receptors for complement components and SRBC. Clin Immunol Immunopathol. 1975 Nov;4(4):545–556. doi: 10.1016/0090-1229(75)90096-3. [DOI] [PubMed] [Google Scholar]
  8. Dickler H. B., Kunkel H. G. Interaction of aggregated -globulin with B lymphocytes. J Exp Med. 1972 Jul 1;136(1):191–196. doi: 10.1084/jem.136.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Froland S. S., Wisloff F., Michaelsen T. E. Human lymphocytes with receptors for IgG. A population of cells distinct from T- and B-lymphocytes. Int Arch Allergy Appl Immunol. 1974;47(1):124–138. doi: 10.1159/000231207. [DOI] [PubMed] [Google Scholar]
  10. Golub E. S. Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells. Cell Immunol. 1971 Aug;2(4):353–361. doi: 10.1016/0008-8749(71)90070-0. [DOI] [PubMed] [Google Scholar]
  11. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Long D. M. Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J Neurosurg. 1970 Feb;32(2):127–144. doi: 10.3171/jns.1970.32.2.0127. [DOI] [PubMed] [Google Scholar]
  13. Mac Dermott R. P., Chess L., Schlossman S. F. Immunologic functions of isolated human lymphocyte subpopulations. V. Isolation and functional analysis of a surface Ig negative, E rosette negative subset. Clin Immunol Immunopathol. 1975 Sep;4(3):415–424. doi: 10.1016/0090-1229(75)90010-0. [DOI] [PubMed] [Google Scholar]
  14. Oger J. F., Arnason B. G., Wray S. H., Kistler J. P. A study of B and T cells in multiple sclerosis. Neurology. 1975 May;25(5):444–447. doi: 10.1212/wnl.25.5.444. [DOI] [PubMed] [Google Scholar]
  15. Osther K., Hojgaard K., Dybkjaer E. Demonstration of a complement of inactivator on cultured cells from human malignant brain tumours. Acta Neurol Scand. 1974;50(6):681–689. doi: 10.1111/j.1600-0404.1974.tb02814.x. [DOI] [PubMed] [Google Scholar]
  16. Owen F. L., Fanger M. W. Studies on the human T-lymphocyte population. II. The use of a T-cell specific antibody in the partial isolation and characterization of the human lymphocyte receptor for sheep red blood cells. J Immunol. 1974 Oct;113(4):1138–1144. [PubMed] [Google Scholar]
  17. Ranney D. F. Biological inhibitors of lymphoid cell division. Adv Pharmacol Chemother. 1975;13:359–408. doi: 10.1016/s1054-3589(08)60235-5. [DOI] [PubMed] [Google Scholar]
  18. Ross G. D., Polley M. J. Specificity of human lymphocyte complement receptors. J Exp Med. 1975 May 1;141(5):1163–1180. doi: 10.1084/jem.141.5.1163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Scheinberg L. C., Levy A., Edelman F. Is the brain an "immunologically privileged site"? 2. Studies in induced host resistance to transplantable mouse glioma following irradiation of prior implants. Arch Neurol. 1965 Sep;13(3):283–286. doi: 10.1001/archneur.1965.00470030063005. [DOI] [PubMed] [Google Scholar]
  20. Shevach E. M., Herberman R., Frank M. M., Green I. Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines. J Clin Invest. 1972 Aug;51(8):1933–1938. doi: 10.1172/JCI106999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Thomas D. G., Lannigan C. B., Behan P. O. Letter: Impaired cell-mediated immunity in human brain tumours. Lancet. 1975 Jun 21;1(7921):1389–1390. doi: 10.1016/s0140-6736(75)92308-9. [DOI] [PubMed] [Google Scholar]
  22. Young H. F., Sakalas R., Kaplan A. M. Inhibition of cell-mediated immunity in patients with brain tumors. Surg Neurol. 1976 Jan;5(1):19–23. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES