Abstract
Studies made of 115 normal subjects of both sexes aged 20--94 years showed that autologous rosette-forming cell levels in human peripheral blood lymphocytes were related to age and sex. However, no such relationship was found in response to phytohaemagglutinin performed in the same subjects. The nature of these autorosettes in human peripheral blood lymphocytes was studied. A significant decrease in autorosette levels was observed after passage through nylon wool at high RBC/WC ratios, and at any ratio after E-rosette depletion. The results suggesting a T-cell origin of autorosettes were confirmed by the existence of mixed autologous erythrocyte and sheep red blood cell rosettes.
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Selected References
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- Bach J. F. Evaluation of T-cells and thymic serum factors in man using the rosette technique. Transplant Rev. 1973;16(0):196–217. doi: 10.1111/j.1600-065x.1973.tb00121.x. [DOI] [PubMed] [Google Scholar]
- Baxley G., Bishop G. B., Cooper A. G., Wortis H. H. Rosetting of human red blood cells to thymocytes and thymus-derived cells. Clin Exp Immunol. 1973 Nov;15(3):385–392. [PMC free article] [PubMed] [Google Scholar]
- Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Charreire J., Bach J. F. Binding of autologous erythrocytes to immature T-cells. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3201–3205. doi: 10.1073/pnas.72.8.3201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gluckman J. C., Montambault P. Letter: Spontaneous autorosettes in man. Lancet. 1975 Jan 11;1(7898):112–113. doi: 10.1016/s0140-6736(75)91130-7. [DOI] [PubMed] [Google Scholar]
- Gluckman J. C., Montambault P. Spontaneous autorosette-forming cells in man. A marker for a subset population of T lymphocytes? Clin Exp Immunol. 1975 Nov;22(2):302–310. [PMC free article] [PubMed] [Google Scholar]
- Greaves M. F., Brown G. Purification of human T and B lymphocytes. J Immunol. 1974 Jan;112(1):420–423. [PubMed] [Google Scholar]
- Hallgren H. M., Buckley C. E., 3rd, Gilbertsen V. A., Yunis E. J. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol. 1973 Oct;111(4):1101–1107. [PubMed] [Google Scholar]
- Kaplan J. Human T lymphocytes form rosettes with autologous and allogeneic human red blood cells. Clin Immunol Immunopathol. 1975 Mar;3(4):471–475. doi: 10.1016/0090-1229(75)90071-9. [DOI] [PubMed] [Google Scholar]
- Preud'homme J. L., Flandrin G. Identification by peroxidase staining of monocytes in surface immunofluorescence tests. J Immunol. 1974 Nov;113(5):1650–1653. [PubMed] [Google Scholar]
- Sandilands G. P., Gray K., Cooney A., Anderson J. R., Simpson J. A., Behan P. O. Letter: Rosette tests following thymectomy. Lancet. 1975 Jan 18;1(7899):171–172. doi: 10.1016/s0140-6736(75)91479-8. [DOI] [PubMed] [Google Scholar]
- Sandilands G. P., Gray K., Cooney A., Browning J. D. Formation of auto-rosettes by peripheral blood lymphocytes. Clin Exp Immunol. 1975 Dec;22(3):493–501. [PMC free article] [PubMed] [Google Scholar]
- Sandilands G., Gray K., Cooney A., Browning J. D., Anderson J. R. Letter: Auto-rosette formation by human thymocytes and lymphocytes. Lancet. 1974 Jan 5;1(7845):27–28. doi: 10.1016/s0140-6736(74)93019-0. [DOI] [PubMed] [Google Scholar]
- Teague P. O., Yunis E. J., Rodey G., Fish A. J., Stutman O., Good R. A. Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity. Lab Invest. 1970 Feb;22(2):121–130. [PubMed] [Google Scholar]
- Weksler M. E., Hütteroth T. H. Impaired lymphocyte function in aged humans. J Clin Invest. 1974 Jan;53(1):99–104. doi: 10.1172/JCI107565. [DOI] [PMC free article] [PubMed] [Google Scholar]