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. 1977 Aug;29(2):311–315.

The effects of azathioprine and levamisole on rosette-forming cells of healthy subjects and cancer patients.

H Verhaegen, W De Cock, J De Cree
PMCID: PMC1541083  PMID: 908176

Abstract

The in vitro effects of azathioprine and levamisole on the capacity of peripheral lymphocytes to form rosettes with sheep erythrocytes were studied in fifteen healthy subjects and forty-one cancer patients. Azathioprine significantly inhibited rosette formation of T lymphocytes in healthy subjects and cancer patients in remission. In contrast, azathioprine could not inhibit rosette formation of T lymphocytes in cancer patients with advanced disease. Patients with advanced tumour had also fewer rosette-forming cells (RFC) than healthy subjects. Levamisole, an anti-anergic chemotherapeutic agent, restored azathioprine-inhibited RFC in healthy subjects and in fifteen out of twenty-two cancer patients. Levamisole alone significantly enhanced low RFC in cancer patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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